Re-evaluation Decision RVD2021-05, Imidacloprid and Its Associated End-use Products

Pest Management Regulatory Agency
19 May 2021
ISSN: 1925-1025 (PDF version)
Catalogue number: H113-28/2021-5-PDF (PDF version)

Summary

Table of contents

• Re-evaluation decision for imidacloprid and associated end use products
• Science evaluation summary
• Re-evaluation decision for imidacloprid
• Risk mitigation measures
• Next steps
• Amended products
• Cancelled products
• Cancelled use with extended phase-out
• Other information
• Appendix I - Registered products containing imidacloprid in Canada

Re-evaluation decision for imidacloprid and associated end use products

Under the authority of the Pest Control Products Act, all registered pesticides must be re-evaluated by Health Canada's Pest Management Regulatory Agency (PMRA) to ensure that they continue to meet current health and environmental standards and continue to have value. The re-evaluation considers data and information from pesticide manufacturers, published scientific reports and other regulatory agencies, as well as comments received during public consultations. Health Canada applies internationally accepted risk assessment methods as well as current risk management approaches and policies.

Imidacloprid is a broad spectrum neonicotinoid insecticide. It is used to manage insects on a large number of agricultural crops, ornamental plants, trees, turf, indoor and outdoor structural sites, and as spot-on application to pets. Imidacloprid products are applied using ground, aerial and seed treatment equipment, tree injection applicators, granular spreaders, pressurized spray cans, brush or paint rollers, spot-on applicators to pets, and as a bait and in bait stations. Currently registered products containing imidacloprid can be found in the Pesticide Label Search and in Appendix I.

The Proposed Re-evaluation Decision PRVD2016-20, Imidacloprid,^Footnote 1 containing an evaluation of imidacloprid and proposed decision, underwent a 120 day consultation period ending on 23 March 2017. PRVD2016-20 proposed the phase-out of all the agricultural and a majority of non-agriculture uses of imidacloprid due to risks to aquatic organisms. Since publication of PRVD2016-20, Health Canada received comments and information relating to the health, environmental and value assessments of imidacloprid. Commenters are listed in Appendix III of RVD2021-05 and the comments are summarized in Appendix IV of RVD2021-05 along with the Health Canada responses. The comments and new data/information received resulted in revisions to the occupational and environmental risk assessments (see Science Evaluation Update), and resulted in changes to the proposed re-evaluation decision as described in PRVD2016-20.

Risks to bees and other pollinators were not a part of this re-evaluation as they were addressed in Health Canada's final re-evaluation decision specifically examining the effects of imidacloprid on pollinators RVD2019-06, Imidacloprid and Its Associated End-use Products: Pollinator Re-evaluation. The mitigation measures put in place as a result of the pollinator re-evaluation are taken into consideration in this re-evaluation decision. The environmental risk of imidacloprid resulting from tree injection uses was previously assessed (ERC2011-03, PRD2016-16 and RD2016-28).

A reference list of information used as the basis for the proposed re-evaluation decision is included in PRVD2016-20, and further information used in the final re-evaluation decision is listed in Appendix XII of RVD2021-05. Therefore, the complete reference list of all information used in this final re-evaluation decision includes both the information set out in PRVD2016-20 and the information set out in Appendix XII of RVD2021-05.

This document (Re-evaluation Decision RVD2021-05, Imidacloprid and Its Associated End-use Products) presents the final re-evaluation decision^Footnote 2 for the re-evaluation of imidacloprid, including the required amendments (risk mitigation measures) to protect human health and the environment, as well as label amendments required to bring labels to current standards. All products containing imidacloprid that are registered in Canada are subject to this re-evaluation decision.

Science evaluation summary

An evaluation of the human health risks associated with imidacloprid has concluded that all uses are acceptable for continued registration with revised label instructions. Some occupational scenarios require revised label directions. Also, some spot-on pet product labels must be brought to current standards. Updates to the assessment can be found in the Science Evaluation Update and Appendix V of RVD2021-05.

Extensive comments and data related to the aquatic invertebrate risk assessment were received. New information included additional toxicity studies and water monitoring data from across Canada. There has been no change to the environmental risk conclusions for turf and lawn uses, and these uses are cancelled. Updates to the assessment of agricultural uses resulted in changes to some of the previous conclusions. Certain uses were not shown to be acceptable and are cancelled. Details are presented in the Science Evaluation Update as well as Appendices VII, VIII, IX and X of RVD2021-05.

Updates were made to the bird and mammal risk assessment based on comments and new information received. Details are presented in the Science Evaluation Update and Appendix VI of RVD2021-05. Risks related to the consumption of imidacloprid-treated seeds by birds and mammals were not shown to be acceptable for some exposure scenarios. Changes to the registrations of some seed treatment uses are required.

Imidacloprid has value as an insecticide used in agriculture, around structures and on pets. Health Canada heard from a number of Canadians on the value of products containing imidacloprid, including information on alternatives which were considered when making the final decision.

Re-evaluation decision for imidacloprid

Health Canada has completed the re-evaluation of imidacloprid. Under the authority of the Pest Control Products Act, Health Canada has determined that continued registration of most products containing imidacloprid is acceptable. An evaluation of available scientific information found that most uses of imidacloprid products meet current standards for protection of human health and the environment and have acceptable value when used according to revised conditions of registration, which includes new mitigation measures. However, certain uses of imidacloprid are cancelled to address potential risks of concern to the environment. Cancelled uses are listed in the Risk mitigation measures Section below. Label amendments, as summarized below and listed in Appendix XI of RVD2021-05, are required.

Risk mitigation measures

Registered pesticide product labels include specific directions for use. Directions include risk mitigation measures to protect human health and the environment and must be followed by law. The required amendments, including any revised/updated label statements and mitigation measures, as a result of the re-evaluation of imidacloprid, are summarized below. Refer to Appendix XI of RVD2021-05 for details.

Cancelled uses due to risks to the environment:

• Seed treatment for corn flea beetle on field and sweet corn. The rate for this pest exceeds the maximum allowable rate of 13 g a.i./80 000 seeds for field corn and 67.2 g a.i./100 kg seed for sweet corn.
• Seed treatment: direct field seeding of brassica vegetables (such as broccoli and cabbage) and leafy vegetables (such as lettuce) and listed pests. Continued registration for transplants only.
• In-furrow application on brassica, leafy, and root and tuber vegetables (including potato) and listed pests. The use on these crops is cancelled due to the maximum application rate being reduced to 100 g a.i./ha or because the maximum allowable rate will be exceeded based on the row spacing for these crops.
• In-furrow application on tobacco and listed pests.
• Soil drench application on brassica, leafy, and root and tuber vegetables (including potato, excluding sugar beet) and listed pests. The use on these crops is cancelled due to the maximum application rate being reduced to 86.6 g a.i./ha or because the maximum allowable rate will be exceeded based on the row spacing for these crops.
• Field application of tray plug drench application on leafy vegetables and listed pests. The use on these crops is cancelled due to the maximum application rate being reduced to 86.6 g a.i./ha.
• Foliar and granular application on turf and listed pests.
• Foliar application on lowbush blueberry and listed pests.

Human health

To protect workers and those entering treated areas, the following risk-reduction measures are required for continued registration of imidacloprid in Canada:

• Changes to personal protective equipment (PPE) and engineering controls for seed treatment uses.
• Update current ventilation statement on the Temprid SC label to include the requirement that ventilation must also occur during application to mitigate inhalation exposure of applicators, as well as any occupants that may enter treated areas following the 6-hour re-entry interval.
• Update commercial labels to current standards by including restricted entry intervals and/or spray drift precautions when they are absent, and clarification that the use in greenhouses is not allowed for uses only registered for outdoor areas.

To better inform the consumer as to the possible effects that may occur following product use, and to clarify the use directions on product labels, the following risk-reduction measure is required for continued registration of imidacloprid in Canada:

• Update labels for spot-on products that have not already been updated according to the 2019 Guidance Document, Label Improvements for Spot-on Pesticides Used on Companion Animals.

Environment

To protect the environment, the following changes to the conditions of use of imidacloprid are required for the following crops:

• Field corn seed treatment: Maximum application rate reduced to 13 g a.i./80 000 seeds.
• Sweet corn seed treatment: Maximum application rate reduced to 67.2 g a.i./100 kg seed.
• Soybean seed treatment: Maximum application rate reduced to 62.5 g a.i./100 kg seed.
• Vegetable seed treatment: Lettuce, broccoli and cabbage seed treatment restricted to crops grown or started (transplant) in greenhouse (no direct seeding to fields permitted).
• Vegetable, potato, legume (except soybean) and tobacco foliar applications: Maximum number of applications reduced to one (1) per season.
• Soybean foliar application: Maximum number of applications reduced to one (1) per season, and maximum application rate reduced to 24.4 g a.i./ha.

Greenhouse uses (soil drench, transplant tray plug drench) are permitted to continue provided that measures are in place to prevent releases, effluent or runoff from greenhouses containing this product from entering lakes, streams, ponds, or other waters. In addition, greenhouses using closed recirculation system (for example, closed chemigation system), the following is required:

• a third-party audit that validates the facility's closed recirculation system and other measures are sufficient to prevent releases, effluent or runoff containing this product from entering lakes, streams, ponds, or other waters.

To protect the environment, the following risk-reduction measures are also required on the label:

• Spray buffer zones are required to mitigate risks from spray drift.
• Standard label statements to inform users of the potential toxic effects to sensitive biota.
• Additional restrictions for use of treated seed, including revisions to seed disposal instructions and the prohibition of broadcast seeding of treated seed.

Required label amendments for all products, where applicable:

• Remove any instructions and/or references from the label for all uses being cancelled, and update the directions for use instructions for any uses with mitigation requirements, as outlined in this re-evaluation decision. This includes but is not limited to application rates, maximum number of applications per year, and re-application intervals.
• Labels are to state the product rates. Any label changes that are required to convert active ingredient rates to product rates must be made by the registrants, and must factor in any formulation-specific calculations, such as specific gravity.
• Labels with structural uses must be amended to adopt the revised definitions for application types outlined in the 2020 PMRA publication PMRA Guidance Document, Structural Pest Control Products: Label Updates.

Next steps

Refer to Appendix I for details on specific products impacted by this decision.

Amended products

To comply with this decision, the required amendments (mitigation measures and label updates)
must be implemented on all product labels no later than 24 months after the publication date of RVD2021-05. Accordingly, both registrants and retailers will have up to 24 months from the date of this decision document to transition to selling the product with the newly amended labels.

Similarly, users will also have the same 24-month period from the date of this decision document to transition to using the newly amended labels, which will be available on the Public Registry.

Cancelled products

Products that are cancelled will be phased out following the implementation timeline outlined below.

• One (1) year of sale by registrant from the publication date of this decision document, followed by;
• One (1) year of sale by retailer from the last date of sale by registrant, followed by;
• One (1) year of permitted use from the last date of sale by retailer.

The transition periods for required amendments and product cancellations will allow for an orderly and safe implementation of these new restrictions and should reduce the risk of product misuse or the improper disposal of products as users switch to alternatives, where required. The risks identified are not considered imminent and serious because they are not expected to cause irreversible harm over these phase-out periods. This approach is consistent with Health Canada's current policy and practice with respect to phase out of uses and products as a result of a re-evaluation (Regulatory Directive DIR2018-01, Policy on Cancellations and Amendments Following Re-evaluation and Special Review).

Cancelled use with extended phase-out

European chafer on the root vegetable ginseng (soil drench) was found to lack suitable alternatives. The effective date of the re-evaluation decision for this use will be delayed for 24 months pursuant to subsection 21(3) of the Pest Control Products Act.

The environmental risks have been determined to be acceptable over this time period on the basis of the current relatively small and fragmented growing areas associated with this crop. Therefore, the continued use for 24 additional months for this imidacloprid use with no suitable alternatives is considered acceptable.

Other information

Any person may file a notice of objection^Footnote 3 regarding this decision on imidacloprid and its associated end-use products within 60 days from the date of publication of this Re-evaluation Decision. For more information regarding the basis for objecting (which must be based on scientific grounds), please refer to the Pesticides section of the Canada.ca website (Request a Reconsideration of Decision) or contact the PMRA's Pest Management Information Service by phone (1-800-267-6315) or by e-mail (hc.pmra-info-arla.sc@Canada.ca).

The relevant confidential test data on which the decision is based (as referenced in PRVD2016-20 and in Appendix XII of RVD2021-05) are available for public inspection, upon application, in the PMRA's Reading Room. For more information, please contact the PMRA's Pest Management Information Service.

Appendix I Registered products containing imidacloprid in Canada

Table 1 Registered products containing imidacloprid in Canada^{Footnote 1} requiring label amendments^{Footnote 2}

Registration number	Marketing class	Registrant	Product name	Formulation type	Guarantee
28936	Technical grade active ingredient	Nufarm Agriculture Inc.	Nufarm Imidacloprid Technical	Solid	Imidacloprid 98%
32242	Manufacturing concentrate	Nufarm Agriculture Inc	Mallet 20 MC	Solution	Imidacloprid 20%
32243	Manufacturing concentrate	Nufarm Agriculture Inc	NUP-14001 MUP	Solution	Imidacloprid 19.19% Lambda-cyhalothrin 3.84%
32645	Technical grade active ingredient	Sharda Cropchem Limited	Imidacloprid Technical Insecticide	Solid	Imidacloprid 98.53%
24468	Technical grade active ingredient	Bayer CropScience Incorporated	Bay NTN 33893 Technical Insecticide	Solid	Imidacloprid 98%
25390	Manufacturing concentrate	Bayer CropScience Incorporated	Merit 75% Concentrate Insecticide	Wettable powder	Imidacloprid 75%
24094	Commercial	Bayer CropScience Incorporated	Admire 240 Flowable Systemic Insecticide	Suspension	Imidacloprid 240 g/L
25636	Commercial	Bayer CropScience Incorporated	Merit 60 WP Greenhouse And Nursery Insecticide	Wettable powder	Imidacloprid 60%
26124	Commercial	Bayer CropScience Incorporated	Gaucho 480 FL Insecticide	Suspension	Imidacloprid 480 g/L
27170	Commercial	Bayer CropScience Incorporated	Gaucho 600 FL Insecticide	Suspension	Imidacloprid 600 g/L
27357	Commercial	Bayer CropScience Incorporated	Intercept 60 WP Greenhouse Insecticide	Wettable powder	Imidacloprid 60%
29609	Commercial	Bayer CropScience Incorporated	Stress Shield For Cereals	Suspension	Imidacloprid 480 g/L
29610	Commercial	Bayer CropScience Incorporated	Stress Shield For Cereals and Soybeans	Suspension	Imidacloprid 480 g/L
29611	Commercial	Bayer CropScience Incorporated	Concept Liquid Insecticide	Suspension	Imidacloprid 75 g/L Deltamethrin 10 g/L
30513	Commercial	Bayer CropScience Incorporated	Maxforce Quantum Ant Bait	Paste	Imidacloprid 0.03%
30668	Commercial	Bayer CropScience Incorporated	Stress Shield 600	Suspension	Imidacloprid 600 g/L
30972	Commercial	Bayer CropScience Incorporated	Sepresto 75 WS	Wettable Powder	Imidacloprid 18.75% Clothianidin 56.25%
31068	Commercial	Bayer CropScience Incorporated	Acceleron IX-409 Insecticide Seed Treatment	Suspension	Imidacloprid 600 g/L
32234	Commercial	Bayer CropScience Incorporated	Quickbayt Granular Fly Bait	Granular	Imidacloprid 0.5% Muscalure 0.09%
32493	Commercial	Bayer CropScience Incorporated	Maxforce Fly Spot Bait	Granular	Imidacloprid 10% Muscalure 0.01%
32523	Commercial	Bayer CropScience Incorporated	Temprid Readyspray	Pressurized products	Imidacloprid 0.05% Beta-cyfluthrin 0.025%
32524	Commercial	Bayer CropScience Incorporated	Temprid SC	Suspension	Imidacloprid 21% Beta-cyfluthrin 10.5%
33014	Commercial	Bayer CropScience Incorporated	Credo SC Insecticide	Suspension	Imidacloprid 526 g/L
33305	Commercial	Bayer CropScience Incorporated	Quickbayt Spot Spray	Wettable granules	Imidacloprid 10% Muscalure 0.1%
29703	Commercial + Restricted	Bayer CropScience Incorporated	Confidor 200 SL	Solution	Imidacloprid 17.1%
30374	Technical grade active ingredient	Adama Agricultural Solutions Canada Limited	MANA Imidacloprid Technical	Solid	Imidacloprid 98.3%
28475	Commercial	Adama Agricultural Solutions Canada Limited	Alias 240 SC Systemic Insecticide	Suspension	Imidacloprid 240 g/L
30505	Commercial	Adama Agricultural Solutions Canada Limited	Sombrero 600 FS	Suspension	Imidacloprid 600 g/L
33562	Commercial	Sharda Cropchem Limited	Sofast Granular Fly Bait	Granular	Imidacloprid 0.5% Muscalure 0.1%
31375	Commercial + Restricted	Arborjet Incorporated	IMA- Jet	Solution	Imidacloprid 58.5 g/L
31479	Commercial + Restricted	Arborjet Incorporated	IMA-Jet 10	Solution	Imidacloprid 117 g/L
25127	Domestic	Elanco Canada Limited	Advantage 55 Flea and Lice Adulticide for Dogs 8 Weeks and Older Weighing between 11 and 25 Kg	Solution	Imidacloprid 9.1%
25128	Domestic	Elanco Canada Limited	Advantage 9 Flea Adulticide for Cats 8 Weeks and Older Weighing 4 Kg and Under	Solution	Imidacloprid 9.1%
25129	Domestic	Elanco Canada Limited	Advantage 18 Flea Adulticide for Cats 8 Weeks and Older Weighing Over 4 Kg	Solution	Imidacloprid 9.1%
25130	Domestic	Elanco Canada Limited	Advantage 10 Flea and Lice Adulticide for Dogs 8 Weeks and Older Weighing 4.5kg & Under	Solution	Imidacloprid 9.1%
25131	Domestic	Elanco Canada Limited	Advantage 100 Flea and Lice Adulticide for Dogs 8 Weeks and Older Weighing More Than 25 Kg	Solution	Imidacloprid 9.1%
25132	Domestic	Elanco Canada Limited	Advantage 20 Flea and Lice Adulticide for Dogs 8 Weeks and Older Weighing Between 4.6 and 11 Kg	Solution	Imidacloprid 9.1%
27581	Domestic	Elanco Canada Limited	Advantage II Small Dog	Solution	Imidacloprid 9.1% Pyriproxifen 0.46%
27582	Domestic	Elanco Canada Limited	Advantage II Large Dog	Solution	Imidacloprid 9.1% Pyriproxifen 0.46%
27583	Domestic	Elanco Canada Limited	Advantage II Medium Dog	Solution	Imidacloprid 9.1% Pyriproxifen 0.46%
27584	Domestic	Elanco Canada Limited	Advantage II Extra Large Dog	Solution	Imidacloprid 9.1% Pyriproxifen 0.46%
27585	Domestic	Elanco Canada Limited	Advantage II small Cat/Rabbit/Ferret	Solution	Imidacloprid 9.1% Pyriproxifen 0.46%
27586	Domestic	Elanco Canada Limited.	Advantage II large Cat/Rabbit	Solution	Imidacloprid 9.1% Pyriproxifen 0.46%
27658	Domestic	Elanco Canada Limited	K9 Advantix 10 Flea, Tick, Mosquito, and Lice Adulticide	Liquid	Imidacloprid 8.8% Permethrin 44%
27659	Domestic	Elanco Canada Limited	K9 Advantix 100 Flea, Tick, Mosquito, and Lice Adulticide	Liquid	Imidacloprid 8.8% Permethrin 44%
27660	Domestic	Elanco Canada Limited	K9 Advantix 55 Flea, Tick, Mosquito, and Lice Adulticide	Liquid	Imidacloprid 8.8% Permethrin 44%
27661	Domestic	Elanco Canada Limited	K9 Advantix 20 Flea, Tick, Mosquito, and Lice Adulticide	Liquid	Imidacloprid 8.8% Permethrin 44%
29777	Domestic	Elanco Canada Limited	K9 Advantix II Small Dog	Solution	Imidacloprid 8.8% Pyriproxifen 0.44% Permethrin 44%
29778	Domestic	Elanco Canada Limited	K9 Advantix II Medium Dog	Solution	Imidacloprid 8.8% Pyriproxifen 0.44% Permethrin 44%
29779	Domestic	Elanco Canada Limited	K9 Advantix II Extra Large Dog	Solution	Imidacloprid 8.8% Pyriproxifen 0.44% Permethrin 44%
29780	Domestic	Elanco Canada Limited	K9 Advantix II Large Dog	Solution	Imidacloprid 8.8% Pyriproxifen 0.44% Permethrin 44%
31517	Domestic	Elanco Canada Limited.	Advantage II Kittens	Liquid	Imidacloprid 9.1% Pyriproxifen 0.46%
31307	Domestic	Fusion Animal Health Incorporated	Primidacide <4 Kg	Solution	Imidacloprid 9.1%
31308	Domestic	Fusion Animal Health Incorporated	Primidacide <4.5 Kg	Solution	Imidacloprid 9.1%
31309	Domestic	Fusion Animal Health Incorporated	Primidacide 4.6-11 Kg	Solution	Imidacloprid 9.1%
31310	Domestic	Fusion Animal Health Incorporated.	Primidacide >4 Kg	Solution	Imidacloprid 9.1%
31311	Domestic	Fusion Animal Health Incorporated	Primidacide >25 Kg	Solution	Imidacloprid 9.1%
31312	Domestic	Fusion Animal Health Incorporated	Primidacide 11-25 Kg	Solution	Imidacloprid 9.1%
33626	Domestic	Fusion Animal Health Incorporated	Primidacide Flea & Tick For Dogs Under 4.5KG	Liquid	Imidacloprid 8.8% Permethrin 44%
33627	Domestic	Fusion Animal Health Incorporated	Primidacide Flea & Tick For Dogs 4.6-11kg	Liquid	Imidacloprid 8.8% Permethrin 44%
33628	Domestic	Fusion Animal Health Incorporated	Primidacide Flea & Tick For Dogs 11-25kg	Liquid	Imidacloprid 8.8% Permethrin 44%
33629	Domestic	Fusion Animal Health Incorporated	Primidacide Flea & Tick For Dogs 25kg And Over	Liquid	Imidacloprid 8.8% Permethrin 44%
31507	Domestic	Brite Ridge Pharmaceuticals Incorporated	Barrier 9	Solution	Imidacloprid 9.1%
31508	Domestic	Brite Ridge Pharmaceuticals Incorporated	Barrier 10	Solution	Imidacloprid 9.1%
31509	Domestic	Brite Ridge Pharmaceuticals Incorporated	Barrier 18	Solution	Imidacloprid 9.1%
31510	Domestic	Brite Ridge Pharmaceuticals Incorporated	Barrier 55	Solution	Imidacloprid 9.1%
31511	Domestic	Brite Ridge Pharmaceuticals Incorporated	Barrier 100	Solution	Imidacloprid 9.1%
31512	Domestic	Brite Ridge Pharmaceuticals Incorporated	Barrier 20	Solution	Imidacloprid 9.1%
31980	Domestic	Wellmark International	Zodiac Infestop Topical Solution For Cats 4 Kg and Under	Solution	Imidacloprid 9.1%
31982	Domestic	Wellmark International	Zodiac Infestop Topical Solution For Dogs 4.5 Kg and Under	Solution	Imidacloprid 9.1%
31983	Domestic	Wellmark International	Zodiac Infestop Topical Solution For Dogs Between 4.6 And 11 Kg	Solution	Imidacloprid 9.1%
31984	Domestic	Wellmark International	Zodiac Infestop Topical Solution For Cats Over 4 Kg	Solution	Imidacloprid 9.1%
31985	Domestic	Wellmark International	Zodiac Infestop Topical Solution For Dogs Over 25 Kg	Solution	Imidacloprid 9.1%
31986	Domestic	Wellmark International	Zodiac Infestop Topical Solution For Dogs Between 11 And 25 Kg	Solution	Imidacloprid 9.1%
32567	Domestic	Virbac Corporation	Preventic Topical Solution Extra Large Dog	Liquid	Imidacloprid 8.8% Permethrin 44%
32573	Domestic	Virbac Corporation	Ectoshield Topical Solution Medium And Large Cat	Solution	Imidacloprid 9.1%
32574	Domestic	Virbac Corporation	Ectoshield Topical Solution Small Cat	Solution	Imidacloprid 9.1%
32581	Domestic	Virbac Corporation	Ectoshield Topical Solution Small Dog	Solution	Imidacloprid 9.1%
32584	Domestic	Virbac Corporation	Ectoshield Topical Solution Extra Large Dog	Solution	Imidacloprid 9.1%
32585	Domestic	Virbac Corporation	Ectoshield Topical Solution Medium Dog	Solution	Imidacloprid 9.1%
32586	Domestic	Virbac Corporation	Preventic Topical Solution Large Dog	Liquid	Imidacloprid 8.8% Permethrin 44%
32588	Domestic	Virbac Corporation	Preventic Topical Solution Medium Dog	Liquid	Imidacloprid 8.8% Permethrin 44%
32589	Domestic	Virbac Corporation	Preventic Topical Solution Small Dog	Liquid	Imidacloprid 8.8% Permethrin 44%
32590	Domestic	Virbac Corporation	Ectoshield Topical Solution Large Dog	Solution	Imidacloprid 9.1%
33173	Domestic	Can-Vet Animal Health Supplies Limited	Bugwacker Flea Protector 9	Solution	Imidacloprid 9.1%
33738	Domestic	Evergreen Animal Health, LLC	Evergreen II Spot on For Extra Large Dogs	Solution	Imidacloprid 7.12% Permethrin 35.6% Pyriproxyfen 0.36%
33739	Domestic	Evergreen Animal Health, LLC	Evergreen II Spot on For on For Large Dogs	Solution	Imidacloprid 7.12% Permethrin 35.6% Pyriproxyfen 0.36%
33740	Domestic	Evergreen Animal Health, LLC	Evergreen II Spot On For Medium Dogs	Solution	Imidacloprid 7.12% Permethrin 35.6% Pyriproxyfen 0.36%
33741	Domestic	Evergreen Animal Health, LLC	Evergreen II Spot On For Small Dogs	Solution	Imidacloprid 7.12% Permethrin 35.6% Pyriproxyfen 0.36%
33789	Domestic	Evergreen Animal Health, LLC	Parapet K9 Praventa 360 for Extra Large Dogs	Solution	Imidacloprid 7.12% Permethrin 35.6% Pyriproxyfen 0.36%
33790	Domestic	Evergreen Animal Health, LLC	Parapet K9 Praventa 360 for Large Dogs	Solution	Imidacloprid 7.12% Permethrin 35.6% Pyriproxyfen 0.36%
33791	Domestic	Evergreen Animal Health, LLC	Parapet K9 Praventa 360 for Medium Dogs	Solution	Imidacloprid 7.12% Permethrin 35.6% Pyriproxyfen 0.36%
33792	Domestic	Evergreen Animal Health, LLC	Parapet K9 Praventa 360 for Small Dogs	Solution	Imidacloprid 7.12% Permethrin 35.6% Pyriproxyfen 0.36%
Footnote 1 as of 11 February 2021, excluding discontinued products or products with a submission for discontinuation Return to footnote 1 referrer Footnote 2 for products co-formulated with other active ingredients, the most restrictive label amendments apply Return to footnote 2 referrer

Table 2 Registered products containing imidacloprid in Canada^{Footnote 1} cancelled as a result of re-evaluation

Registration number	Marketing class	Registrant	Product name	Formulation type	Guarantee
25932	Commercial	Bayer CropScience Incorporated	Merit Solupack Insecticide	Wettable powder	Imidacloprid 75%
25933	Commercial	Bayer CropScience Incorporated	Merit Granular	Granular	Imidacloprid 0.5%
29130	Commercial	Adama Agricultural Solutions Canada Limited	Quali-Pro Imidacloprid 75 WSP Insecticide	Wettable powder	Imidacloprid 75%
29185	Commercial	Adama Agricultural Solutions Canada Limited	Quali-Pro Imidacloprid 0.5 Granular Insecticide	Granular	Imidacloprid 0.5%
29738	Domestic	SBM Life Science Corporation	BioAdvanced Science-Based Solutions Season Long Grub Control	Granular	Imidacloprid 0.25%
Footnote 1 as of 11 February 2021, excluding discontinued products or products with a submission for discontinuation Return to footnote 1 referrer