Final Assessment

List of Abbreviations

ADI

acceptable daily intake

a.i.

active ingredient

AUC

area under the plasma concentration versus time curve

BAF

bioaccumulation factor

BASL4

Biosolids-Amended Soil Level 4

BCF

bioconcentration factor

BMDL

lower 95% confidence limit on the benchmark dose

bw

body weight

CAF

composite assessment factor

CAR

constitutive androstane receptor

CAS

Chemical Abstracts Service

CEPA 1999

Canadian Environmental Protection Act, 1999

CMA

Chemical Manufacturers' Association

C_max

maximum concentration in plasma

CTV

critical toxicity value

CYP

cytochrome P450

DCDD

dichlorodibenzo-p-dioxin

DCP

dichlorophenol

DNA

deoxyribonucleic acid

DNT

developmental neurotoxicity

DSL

Domestic Substances List

DT₅₀

median dissipation time

dw

dry weight

EC

effective concentration

EU

European Union

FIFRA

Federal Insecticide, Fungicide, and Rodenticide Act

GUS

groundwater ubiquity score

HC5

hazardous concentration to 5% of species

HPV

high production volume

IC

inhibitory concentration

IUPAC

International Union of Pure and Applied Chemistry

K_d

soil/water partition coefficient

K_oa

octanol/air partition coefficient

K_oc

soil organic carbon partition coefficient

K_ow

n-octanol/water partition coefficient

LC₅₀

median lethal concentration

LD₅₀

median lethal dose

LOAEL

lowest-observed-adverse-effect level

LOD

limit of detection

LOEC

lowest-observed-effect concentration

LOEL

lowest-observed-effect level

LOQ

limit of quantification

MATC

maximum allowable toxicant concentration

MDL

method detection limit

MITI

Ministry of International Trade and Industry (Japan)

MOA

mode of action

MOE

margin of exposure

MQL

method quantification limit

NHANES

National Health and Nutrition Examination Survey (United States)

NICNAS

National Industrial Chemicals Notification and Assessment Scheme (Australia)

NITE

National Institute of Technology and Evaluation (Japan)

NOAEL

no-observed-adverse-effect level

NOEC

no-observed-effect concentration

NOEL

no-observed-effect level

OECD

Organisation for Economic Co-operation and Development

P4

Plastic and Personal-Care Product Use in Pregnancy

PCDD

polychlorinated dibenzodioxin

PCDF

polychlorinated dibenzofuran

PCPA

Pest Control Products Act

PEC

predicted environmental concentration

pK_a

-log ₁₀ acid dissociation constant

PMRA

Pest Management Regulatory Agency

PND

postnatal day

PNEC

predicted no-effect concentration

PPAR

peroxisome proliferator-activated receptor

ppb

parts per billion

ppm

parts per million

PXR

pregnane X receptor

QSAR

quantitative structure-activity relationship

RED

Reregistration Eligibility Decision

RN

registry number

RNA

ribonucleic acid

SCCP

Scientific Committee on Consumer Products

SCCS

Scientific Committee on Consumer Safety

SIDS

Screening Information Data Set

SCENIHR

Scientific Committee on Emerging and Newly Identified Health Risks

SSD

species sensitivity distribution

t½

half-life

T₃

triiodothyronine

T₄

thyroxine

TCDD

tetrachlorodibenzo-p-dioxin

TR

thyroid receptor

TriCDD

trichlorodibenzo-p-dioxin

TSH

thyroid-stimulating hormone

TSMP

Toxic Substances Management Policy

US EPA

United States Environmental Protection Agency

ww

wet weight

WWTP

wastewater treatment plant