Abanobi, S.E., Farber, E. et Sarma, D.S.R. (1979). Persistence of DNA damage during development of liver angiosarcoma in rats fed dimethylnitrosamine. Cancer Res., 39:1592-1596.
Agrelo, C., Phillips, J.C., Lake, B.G., Longland, R.C. et Gangolli, S.D. (1978). Studies on the gastrointestinal absorption of N-nitrosamines: effect of dietary constituents. Toxicology, 10:159-167.
Alexandrov, V.A. (1968). Blastomogenic effect of dimethylnitrosamine on pregnant rats and their offspring. Nature, 218:280-281.
Althoff, J., Grandjean, C. et Pour, P. (1977). Transplacental effects of nitrosamines in Syrian hamsters. Z. Krebsforsch., 90:79-86.
Anderson, L.M., Giner-Sorolla, A. et Ebeling, D. (1978). Effects of imipramine, nitrite, and dimethylnitrosamine on reproduction in mice. Res. Commun. Chem. Pathol. Pharmacol., 19:311-327.
Anderson, L.M., Priest, L.J. et Budinger, J.M. (1979). Lung tumorigenesis in mice after chronic exposure in life to a low dose of dimethylnitrosamine. J. Natl. Cancer Inst., 62:1553-1555.
Anderson, L.M., Harrington, G.W., Pylypiw, H.M., Hagiwara, A. et Magee, P.N. (1986). Tissue levels and biological effects of N-nitrosodimethylamine in mice during chronic low or high dose exposure with or without ethanol. Drug Metab. Dispos., 14(6):733-739.
Anderson, L.M., Hagiwqra, A., Robert, M., Kovatch, R.M., Rehm, S. et Rice, J.M. (1989). Transplacental initiation of liver, lung, neurogenic, and connective tissue tumors by N-nitroso compounds in mice. Fundam. Appl. Toxicol., 12:604-620.
Anderson, L.M., Carter, J.P., Logsdon, D.L., Driver, C.L. et Kovatch, R.M. (1992). Characterization of ethanol's enhancement of tumorigenesis by N-nitrosodimethylamine in mice. Carcinogenesis, 13:2107-2111.
Anderson, L.M., Souliotis, V.L., Chhabra, S.K., Moskal, T.J., Harbaugh, S.D. et Kyrtopoulos, S.A. (1996). N-Nitrosodimethylamine-derived O6-methylguanine in DNA of monkey gastrointestinal and urogenital organs and enhancement by ethanol. Int. J. Cancer, 66:130-134.
APHA, AWWA et WEF (2005). Standard methods for the examination of water and wastewater. 21st edition. American Public Health Association, Washington, DC.
Arai, M., Aoki,Y., Nakanishi, K., Miyata, Y., Mori, T. et Ito, N. (1979). Long-term experiment of maximal non-carcinogenic dose of dimethylnitrosamine for carcinogenesis in rats. Gann, 70:549-558.
Asakura, S., Sawada, S., Daimon, H., Fukuda, T., Ogura, K., Yamatsu, K. et Furihata, C. (1994). Effects of dietary restriction on induction of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) in rat liver. Mutat. Res., 322:257-264.
Atkinson, R. (1985). Kinetics and mechanisms of the gas-phase reactions of hydroxyl radicals with organic compounds under atmospheric conditions. Chem. Rev., 85:69-201.
ATSDR (1989). Toxicological profile for N-nitrosodimethylamine. Préparé par le Syracuse Research Corporation en collaboration avec la U.S. Environmental Protection Agency. Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Washington, DC. 119 p.
Ayanaba, A. et Alexander, M. (1974). Transformation of methylamines and formation of a hazardous product, dimethylnitrosamine, in samples of treated sewage and lake water. J. Environ. Qual., 3:83-89.
Barbin, A., Béréziat, J.-C. et Bartsch, H. (1983). Evaluation of DNA damage by the alkaline elution technique in liver, kidneys and lungs of rats and hamsters treated with N-nitroso-dialkylamines. Carcinogenesis, 4:541-545.
Barnes, J.M. et Magee, P.N. (1954). Some toxic properties of dimethylnitrosamine. Br. J. Ind. Med., 11:167-174 [cité dans ATSDR, 1989].
Barrett, S., Hwang, C., Guo, Y., Andrews, S.A. et Valentine, R. (2003). Occurrence of NDMA in drinking water: a North American survey, 2001-2002. Dans : Proceedings of the American Water Works Association's Annual Conference, Anaheim, CA, June 15-19, 2003. American Water Works Association, Denver, Colorado.
Bauknecht, T., Vogel, W., Bayer, U. et Wild, D. (1977). Comparative in vivo mutagenicity testing by SCE and micronucleus induction in mouse bone marrow. Hum. Genet., 35:299-307.
Bermudez, E., Mirsalis, J.C. et Eales, H.C. (1982). Detection of DNA damage in primary cultures of rat hepatocytes following in vivo and in vitro exposure to genotoxic agents. Environ. Mutagen., 4:667-679.
Biaudet, H., Mouillet, L. et Debry, G. (1997). Migration of nitrosamines from condoms to physiological secretions. Bull. Environ. Contam. Toxicol., 59:847-853.
Bolognesi, C., Rossi, L. et Santi, L. (1988). A new method to reveal the genotoxic effects of N-nitrosodimethylamine in pregnant mice. Mutat. Res., 207:57-62.
Bolton, J.R. et Stefan, M.I. (2000). UV-photodegradation as a treatment technology for N-nitrosodimethylamine (NDMA). Dans : Proceedings of the American Water Works Association Water Quality and Technology Conference, Salt Lake City, UT, November 5-9, 2000. American Water Works Association, Denver, Colorado.
Braithwaite, I. et Ashby, J. (1988). A non-invasive micronucleus assay in the rat liver. Mutat. Res., 203:23-32.
Brambilla, G., Cavanna, M., Pino, A. et Robbiano, L. (1981). Quantitative correlation among DNA damaging potency of six N-nitroso compounds and their potency in inducing tumor growth and bacterial mutations. Carcinogenesis, 2:425-429.
Brambilla, G., Carlo, P., Finollo, R. et Sciabà, L. (1987). Dose-response curves for liver DNA fragmentation induced in rats by sixteen N-nitroso compounds as measured by viscometric and alkaline elution analyses. Cancer Res., 47:3485-3491.
Brantom, P.G. (1983). Dose-response relationships in nitrosamine carcinogenesis. Thèse de doctorat. University of Surrey, Guildford, United Kingdom. British Industrial Biological Research Association (BIBRA), Carshalton, Surrey, United Kingdom, 158 pp.
Brendler, S.Y., Tompa, A., Hutter, K.F., Preussmann, R. et Pool-Zobel, B.L. (1992). in vivo and in vitro genotoxicity of several N-nitrosamines in extrahepatic tissues of the rat. Carcinogenesis, 13:2435-2441.
Brunnemann, K.D. et Hoffmann, D. (1978). Analysis of volatile nitrosamines in tobacco smoke and polluted indoor environments. Chemical studies on tobacco smoke LIX. IARC Sci. Publ., 19:343-356.
Budavari, S., O'Neil, M.J., Smith, A.S. et Heckelman, P.E. (1989). The Merck index-An encyclopedia of chemicals, drugs, and biologicals. 11e édition. Merck and Co., Inc., Rahway, New Jersey.
Butterworth, B.E., Templin, M.V., Constan, A.A., Sprankle, C.S., Wong, B.A., Pluta, L.J., Everitt, J.I. et Recio, L. (1998). Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lac I transgenic B6C3F1 mice. Environ. Mol. Mutagen., 31:248-256.
Callahan, M.A., Slimak, M.W., Gabel, N.W., May I.P., Fowler, C.F., Freed, J.R., Jennings, P., Durfee, R.L., Whitemore, F.C., Maestri, B., Mabey, W.R., Holt, B.R. et Gould, C. (1979). Water related environmental fate of 129 priority pollutants. Versar, Inc., Springfield, VA (EPA-440-4-79-029a,b).
Carter, R.L., Percival, W.H. et Roe, F.J.C. (1969). Exceptional sensitivity of mink to the hepatotoxic effects of dimethylnitrosamine. J. Pathol., 97:79-88 [cité dans ATSDR, 1989].
Cesarone, C.F., Bolognesi, C. et Santi, L. (1979). DNA repair synthesis in mice spermatids after treatment with N-methyl-N-nitroso-urea and N,N-dimethylnitrosamine: preliminary results. Toxicology, 12:183-186.
Cesarone, C.F., Bolognesi, C. et Santi, L. (1982). Evaluation of damage to DNA after in vivo exposure to different classes of chemicals. Arch. Toxicol. Suppl. 5:355-359.
Charrois, J.W.A. et Hrudey, S.E. (2007). Breakpoint chlorination and free-chlorine contact time: implications for drinking water N-nitrosodimethylamine concentrations. Water Res., 41:674-682.
Charrois, J.W.A., Arend, M.W., Froese, K.L. et Hrudey, S.E. (2004). Detecting N-nitrosamines in drinking water at nanogram per liter levels using ammonia positive chemical ionization. Environ. Sci. Technol., 38(18):4835-4841.
Charrois, J.W.A., Boyd, J.M., Froese, K.L. et Hrudey, S.E. (2007). Occurrence of N-nitrosamines in Alberta public drinking-water distribution systems. J. Environ. Eng. Sci. 6:103-114.
Chen Z. et Valentine, R.L. (2007). Formation of N-Nitrosodimethylamine (NDMA). from humic substances in natural water. Environ. Sci. Technol., 41(17):6059-6065.
Cheng, R., Hwang, C.J., Andrews-Tate, C., Guo Y.C., Carr, S. et Suffet, I.H. (2006). Alternative methods for the analysis of NDMA and other nitrosamines in water. J. Am. Water Works Assoc., 98(12):82-96.
Chhabra, S.K., Souliotis, V.L., Jones, A.B., Anderson, L.M. et Kyrotopoulos, S.A. (1995). O-Methylguanine DNA-adduct formation and modulation by ethanol in placenta and fetal tissues after exposure of pregnant patas monkeys to N-nitrosodimethylamine. Proc. Am. Assoc. Cancer Res., 36:150.
Choi, J. et Valentine, R.L. (2002a). Formation of N-nitrosodimethylamine (NDMA) from reaction of monochloramine: a new disinfection by-product. Water Res., 36(4):817-824.
Choi, J. et Valentine, R.L. (2002b). A kinetic model of N-nitrosodimethylamine (NDMA) formation during water chlorination/chloramination. Water Sci. Technol., 46(3):65-71.
Choi, J. et Valentine, R.L. (2003). N-Nitrosodimethylamine formation by free-chlorine-enhanced nitrosation of dimethylamine. Environ. Sci. Technol., 37(21):4871-4876.
CIRC (1987). Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1-42. IARC Monogr. Eval. Carcinog. Risk Chem. Hum. Suppl. 7.
Clapp, N.K. et Toya, R.E. (1970). Effect of cumulative dose and dose rate on dimethyl-nitrosamine oncogenesis in RF mice. J. Natl. Cancer Inst., 45:495-498.
Clayton, G. et Clayton, F. (eds.) (1981). Patty's industrial hygiene and toxicology. 3e édition. John Wiley and Sons, New York, NY. p. 2786-2788.
Cliet, I., Fournier, E., Melcion, C. et Cordier, A. (1989). In vivo micronucleus test using mouse hepatocytes. Mutat. Res., 216:321-326.
Cliet, I., Melcion, C. et Cordier, A. (1993). Lack of predictivity of bone marrow micronucleus test versus testis micronucleus test: comparison with four carcinogens. Mutat. Res., 292:105-111.
Coccia, P., Salmona, M., Diomede, L., Citti, L., Mariani, L. et Romano, M.. (1988). Liver DNA alkylation after a single carcinogenic dose of dimethylnitrosoamine to newborn and adult CFW Swiss mice. Chem. Biol. Interact., 68:259-271.
Collaborative Study Group for the Micronucleus Test (1986). Sex difference in the micronucleus test. Mutat. Res., 172:151-163.
Conestoga-Rovers & Associates (1994). Treatability test report for Conestoga-Rovers & Associates on Rayox UV/oxidation treatment of Uniroyal off-site groundwater. Conestoga-Rovers & Associates, Waterloo, Ontario, décembre [cité dans PISSC, 2002].
Daugherty, J.P. et Clapp, N.K. (1976). Studies on nitrosamine metabolism: I. Subcellular distribution of radioactivity in tumor-susceptible tissues of RFM mice following administration of (14C)dimethylnitrosamine. Life Sci., 19:265-271 [cité dans ATSDR, 1989].
De Stefani, E., Deneo-Pellegrini, H., Carzoglio, J.C., Ronco, A. et Mendilaharsu, M. (1996). Dietary nitrosodimethylamine and the risk of lung cancer: a case-control study from Uruguay. Cancer Epidemiol. Biomarkers Prev., 5:679-682.
Devereux, T.R., Anderson, M.W. et Belinsky, S.A. (1991). Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumours in the resistant C3H mouse. Carcinogenesis, 12:299-303.
Diaz Gomez, M.I., Swann, P.F. et Magee, P.N. (1977). The absorption and metabolism in rats of small oral doses of dimethylnitrosamine. Biochem. J., 164:497-500.
Diaz Gomez, M.I., Tamayo, D. et Castro, J.A. (1986). Administration of N-nitrosodimethylamine, N-nitrosopyrrolidine, or N-nitrosonornicotine to nursing rats: their interactions with liver and kidney nucleic acids from sucklings. J. Natl. Cancer Inst., 76(6):1133-1136.
DMER et AEL (1996). Pathways analysis using fugacity modelling of N-nitrosodimethylamine for the second Priority Substances List. Préparé pour la Division de l'évaluation des produits chimiques, Direction de l'évaluation des produits chimiques commerciaux, Environnement Canada, Hull, Québec. Don Mackay Environmental Research, Peterborough, Ontario; et Angus Environmental Limited, Don Mills, Ontario. 63 p.
Doolittle, D.J., Bermudez, E., Working, P.K. et Butterworth, B.E. (1984). Measurement of genotoxic activity in multiple tissues following inhalation exposure to dimethylnitrosamine. Mutat. Res., 141:123-127.
ECETOC (1990). Human exposure to N-nitrosamines, their effects, and a risk assessment for N-nitrosodiethanolamine in personal care products. European Centre for Ecotoxicology and Toxicology of Chemicals, Bruxelles (Technical Report No. 41) [cité dans PISSC, 2002].
Environnement Canada (1997). Results of the CEPA Section 16 Notice respecting the second Priority Substances List and di(2-ethylhexyl)phthalate. Section de l'utilisation des produits, Direction de l'évaluation des produits chimiques commerciaux, Hull, Québec.
Environnement Canada et Santé Canada (2001). Liste des substances d'intérêt prioritaire - Rapport d'évaluation pour N-Nitrosodiméthylamine (NDMA). Ottawa, Ontario.
Fitzgerald, D.J. et Robinson, N.I. (2007). Development of a tolerable daily intake for N-nitrosodimethylamine using a modified benchmark dose methodology. J. Toxicol. Environ. Health A, 70(19):1670-1678.
Fleming, E.C., Pennington, J.C., Wachob, B.G., Howe, R.A. et Hill, D.O. (1996). Removal of N-nitrosodimethylamine from waters using physical-chemical techniques. J. Hazard. Mater., 51(1/3):151-164.
Fristachi, A. anetd Rice, G. (2007). Estimation of the total intake of NDMA attributable to drinking water. J. Water Health 5:341-355.
Fussgänger, R.D. et Ditschuneit, H. (1980). Lethal exitus of a patient with N-nitroso-dimethylamine poisoning 2.5 years following the first ingestion and signs of intoxication. Oncology, 37:273-277.
Gerecke, A.C. et Sedlak, D.L. (2003). Precursors of N-nitrosodimethylamine in natural waters. Environ. Sci. Technol., 37(7):1331-1336.
Goff, E.U., Coombs, J.R. et Fine, D.H. (1980). Determination of N-nitrosamines from diesel engine crankcase emissions. Anal. Chem., 52:1833-1836.
Gombar, C.T., Harrington, G.W., Pylypiw, H.M., Jr., Anderson, L.M., Palmer, A.E., Rice, J.M., Magee, P.N. et Burak, E.S. (1990). Interspecies scaling of the pharmacokinetics of N-nitrosodimethylamine. Cancer Res., 50(14):4366-4370.
González, C.A., Riboli, E., Badosa, J., Batiste, E., Cardona, T., Pita, S., Sanz, J.M., Torrent, M. et Agudo, A. (1994). Nutritional factors and gastric cancer in Spain. Am. J. Epidemiol., 139:466-473.
Goodman, M.T., Hankin, J.H., Wilkens, L.R. et Kolonel, L.N. (1992). High-fat foods and the risk of lung cancer. Epidemiology, 3:288-299.
Haggerty, H.G. et Holsapple, M.P. (1990). Role of metabolism in dimethylnitrosamine-induced immunosuppression: a review. Toxicology, 63:1-23.
Hakura, A., Suzuki, S. et Satoh, T. (1999). Advantage of the use of human liver S9 in the Ames test. Mutat. Res., 438:29-36.
Hakura, A., Suzuki, S., Sawada, S., Sugihara, T., Hori, Y., Uchida, K., Kerns, W.D., Sagami, F., Motooka, S. et Satoh, T. (2003). Use of human liver S9 in the Ames test: assay of three procarcinogens using human S9 derived from multiple donors. Regul. Toxicol. Pharmacol., 37:20-27.
Hanst, P.L., Spence, J.W. et Miller, M. (1977). Atmospheric chemistry of N-nitroso dimethylamine. Environ. Sci. Technol., 11(4):403-405.
Hard, G.C. et Butler, W.H. (1970a). Cellular analysis of renal neoplasia: light microscope study of the development of interstitial lesions induced in the rat kidney by a single carcinogenic dose of dimethylnitrosamine. Cancer Res., 30:2806-2815.
Hard, G.C. et Butler, W.H. (1970b). Toxicity of dimethylnitrosamine for the rat testis. J. Pathol., 102:201-207.
Haruta, S., Chen, W., Gan, J., Simunex, J., Chang, A.C. et Wu, L. (2008). Leaching risk of N-nitrosodimethylamine (NDMS) in soil receiving reclaimed Wastewater. Ecotoxicology and Environental Safety 69:374-380.
Hashimoto, S., Yokokura, T., Kawai, Y. et Mutai, M. (1976). Dimethylnitrosamine formation in the gastro-intestinal tract of rats. Food Cosmet. Toxicol., 14:553-556.
Herron, D.C. et Shank, R.C. (1980). Methylated purines in human liver DNA after probable dimethylnitrosamine poisoning. Cancer Res., 40:3116-3117.
Hoffmann, D., Brunnemann, K.D., Adams, J.D. et Hecht, S.S. (1984). Formation and analysis of N-nitrosamines in tobacco products and their endogenous formation in consumers. IARC Sci. Publ., 57:743-762.
Hoffmann, D., Adams, J.D. et Brunnemann, K.D. (1987). A critical look at N-nitrosamines in environmental tobacco smoke. Toxicol. Lett., 35:1-8.
Howard, P.H., Boethling, R.S., Jarvis, W.F., Meylan, W.M. and Michalenko, E.M. (eds.) (1991). Handbook of environmental degradation rates. Lewis Publishers Inc., Chelsea, Michigan.
Inui, N., Nishi, Y., Taketomi, M. et Mori, M. (1979). Transplacental action of sodium nitrite on embryonic cells of Syrian golden hamster. Mutat. Res., 66:149-158.
Ireland, D. (1989). Information report on drinking water quality, Elmira, Ontario. Division des opérations régionales, ministère de l'Environnement de l'Ontario, Cambridge, Ontario. 14 novembre (rapport non publié).
Ito, N., Fukushima, S., Tsuda, H. et Shirai, T. (1982). Induction of preneoplastic and neoplastic lesions in rats treated with N-nitroso compounds. IARC Sci. Publ., 41:597-601.
Johansson-Brittebo, E. et Tjälve, H. (1979). Studies on the distribution and metabolism of 14C-dimethylnitrosamine in foetal and young mice. Acta Pharmacol. Toxicol., 45:73-80.
Jorquera, R., Castonguay, A. et Schuller, H.M. (1993). Effects of age and ethanol on DNA single-strand breaks and toxicity induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or N-nitrosodimethylamine in hamster and rat liver. Cancer Lett., 74:175-181.
Khanna, S.D. et Puri, D. (1966). The hepatotoxic effects of dimethylnitrosamine in the rat. J. Pathol. Bacteriol., 91:605-608 [cité dans ATSDR, 1989].
Kimoto, W.I., Dooley, C.J., Carré, J. et Fiddler, W. (1980). Role of strong ion exchange resins in nitrosamine formation in water. Water Res., 14(7):869-876.
Klus, H., Begutter, H., Scherer, G., Tricker, A.R. et Adlkofer, F. (1992). Tobacco-specific and volatile N-nitrosamines in environmental tobacco smoke of offices. Indoor Environ., 1:348-350.
Knekt, P., Järvinen, R., Dich, J. et Hakulinen, T. (1999). Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite and N-nitroso compounds: a follow-up study. Int. J. Cancer, 80:852-856.
Kommineni, S., Ela, W.P., Arnold, R.G., Huling, S.G., Hester, B.J. et Betterton, E.A. (2003). NDMA treatment by sequential GAC adsorption and Fenton-driven destruction. J. Environ. Eng. Sci., 20(4):361-373.
Kornbrust, D. et Dietz, D. (1985). Aroclor 1254 pretreatment effects on DNA repair in rat hepatocytes elicited by in vivo or in vitro exposure to various chemicals. Environ. Mutagen., 7:857-870.
Kornelsen, P.J., Hallett, D.J. et Brecher, R.W. (1989). Special report to Regional Municipality of Waterloo. Contamination of Elmira drinking water with N,N-dimethylnitrosamine. ELI Eco Logic International Inc., Rockwood, Ontario. 14 décembre.
Krishna, G., Kropko, M.L. et Theiss, J.C. (1990). Dimethylnitrosamine induced micronucleus formation in mouse bone marrow and spleen. Mutat. Res., 242:345-351.
Krishnan, K. (2004). Development of a two tier approach for evaluating the relevance of multiroute exposures in establishing drinking water goals for volatile organic chemicals. Rapport rédigé pour le compte du Bureau de la qualité de l'eau et de la santé, Programme de la sécurité des milieux, Santé Canada. Décembre (contrat no 602-453088364).
Kunisaki, N., Matsuura, H. et Hayashi, M. (1978). [Absorption et décomposition de la N-nitrosodimethylamine chez les rats.] Shokuhin Eiseigaku Zasshi, 19(1):62-67 (en japonais).
Lachmaniuk, P. (1998). Ontario drinking water surveillance program: 1990-July 1998 survey of Ontario water treatment plants. Données non publiées. Ministère de l'Environnement de l'Ontario, Toronto, Ontario [cité dans PISSC, 2002].
Laishes, B.A., Koropatnick, D.J. et Stich, H.F. (1975). Organ-specific DNA damage induced in mice by the organotropic carcinogens 4-nitroquinoline-1-oxide and dimethylnitrosamine. Proc. Soc. Exp. Biol. Med., 149:978-982.
La Vecchia, C., D'Avanzo, B., Airoldi, L., Braga, C. et Decarli, A. (1995). Nitrosamine intake and gastric cancer. Eur. J. Cancer Prev., 4:469-474.
Lee, C., Choi, W., Kim, Y.G. et Yoon, J. (2005). UV photolytic mechanism of N-nitrosodimethylamine in water: dual pathways to methylamine versus dimethylamine. Environ. Sci. Technol., 39(7):2101-2106.
Lee, C., Schmidt, C., Yoon, J. et Von Gunten, U. (2007a). Oxidation of N-nitrosodimethylamine (NDMA) precursors with ozone and chlorine dioxide: kinetics and effect on NDMA formation potential. Environ. Sci. Technol., 41(6):2056-2063.
Lee, C., Yoon, J. et Von Gunten, U. (2007b). Oxidative degradation of N-nitrosodimethylamine by conventional ozonation and the advanced oxidation process ozone/hydrogen peroxide. Water Res., 41:581-590.
Lee, V.M., Keefer, L.K. et Archer, M.C. (1996). An evaluation of the roles of metabolic denitrosation and α-hydroxylation in the hepatotoxicity of N-nitrosodimethylamine. Chem. Res. Toxicol., 9:1319-1324.
Liang, S., Min, J.H., Davis, M.K., Green, J.F. et Remer, D.S. (2003). Use of pulsed-UV processes to destroy NDMA. J. Am. Water Works Assoc., 95(9):121-131.
Lijinsky, W. (1999). N-Nitroso compounds found in the diet. Mutat. Res., 443:129-138.
Lijinsky, W. et Reuber, M.D. (1984). Carcinogenesis in rats by nitrosodimethylamine and other nitrosomethylalkylamines at low doses. Cancer Lett., 22:83-88.
Lindamood, C., III, Bedell, M.A., Billings, K.C., Dyroff, M.C. et Swenberg, J.A. (1984). Dose response for DNA alkylation, [³H]thymidine uptake into DNA, and O6-methylguanine-DNA methyltransferase activity in hepatocytes of rats and mice continuously exposed to dimethylnitrosamine. Cancer Res., 44:196-200.
Loury, D.J., Smith-Oliver, T. et Butterworth, B.E. (1987). Assessment of unscheduled and replicative DNA synthesis in rat kidney cells exposed in vitro or in vivo to unleaded gasoline. Fundam. Appl. Toxicol., 87:127-140.
Magee, P.N. et Barnes, J.M. (1962). Induction of kidney tumours in the rat with dimethyl-nitrosamine (N-nitrosodimethylamine). J. Pathol. Bacteriol., 84:19-31.
Mallik, M. et Tesfai, K. (1981). Transformation of nitrosamines in soil and in vitro by soil microorganisms. Bull. Environ. Contam. Technol., 27:115-121.
Martino, P.E., Diaz Gomez, M.I., Tamayo, D., Lopez, A.J. et Castro, J.A. (1988). Studies on the mechanism of the acute and carcinogenic effects of N-nitrosodimethylamine on mink liver. J. Toxicol. Environ. Health, 23:183-192.
McBean, E. (1999). Communication personnelle (courriel envoyé le 30 mai 1999). Conestoga-Rovers & Associates, Waterloo, Ontario [cité dans PISSC, 2002].
McKone, T.E. et Knezovich, J.P. (1991). The transfer of trichloroethylene from a shower to indoor air: experimental measurements and their implications. J. Air Waste Manage. Assoc., 40:282-286.
McLean, A.E.M. et Magee, P.N. (1970). Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats. Br. J. Exp. Pathol., 51:587-590.
Mehta, R., Silinskas, K.C., Zucker, P.F., Ronen, A., Heddle, J.A. et Archer, M.C. (1987). Micronucleus formation induced in rat liver and esophagus by nitrosamines. Cancer Lett., 35:313-320.
MEO (1990). Document technique d'A. Ng à G. De Brou, le 27 avril 1990, concernant l'enquête effectuée à Elmira (1990) : Résultats du laboratoire mobile TAGA; note d'accompagnement du 5 mai 1990 de L. Lusis à E. Piché concernant le rapport d'enquête sur la NDMA à Elmira, avril 1990. Ministère de l'Environnement de l'Ontario, Toronto, Ontario [cité dans PISSC, 2002].
MEO (1991). N-Nitrosodimethylamine. Direction de la coordination des contaminants dangereux, ministère de l'Environnement de l'Ontario, Toronto, Ontario. 64 p. (Scientific Criteria Document for Multimedia Standard Development No. 01-90).
MEO (1992). Document technique d'A. Ng à M. Lusis, le 24 juillet 1992, concernant l'enquête effectuée à Kitchener (1992) : NC Rubber Products Inc.- Résultats du laboratoire mobile TAGA6000; note d'accompagnement du 28 juillet 1992 de M. Lusis à D. Ireland concernant l'enquête réalisée à l'aide du laboratoire mobile TAGA6000 par NC Rubber Products Inc., ministère de l'Environnement de l'Ontario, Toronto, Ontario [cité dans PISSC, 2002].
MEO (1994). Removal of N-nitrosodimethylamine from the Ohsweken (Six Nations) water supply. Rapport final. Ministère de l'Environnement de l'Ontario, Toronto, Ontario. Novembre. 10 p. + annexe (ISBN 0-7778-3439-1).
MEO (1996). Ontario drinking water surveillance program: 1994-1996 survey of Ontario water treatment plants. Données non publiées. Environnement et Énergie Ontario, Toronto, Ontario. 9 p. [cité dans PISSC, 2002].
MEO (2009). Données du Programme de surveillance de l'eau potable de l'Ontario. Dernière consultation : mars 2009.
Mirsalis, J.C. et Butterworth, B.E. (1980). Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo-in vitro assay for potential carcinogens and mutagens. Carcinogenesis, 1:621-625.
Mirsalis, J.C., Tyson, C.K., Steinmetz, K.L., Loh, E.K., Hamilton, C.M., Bakke, J.P. et Spalding, J.W. (1989). Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment: testing of 24 compounds. Environ. Mol. Mutagen., 14:155-164.
Mirsalis, J.C., Provost, G.S., Matthews, C.D., Hamner, R.T., Schindler, J.E., O'Loughlin, K.G., MacGregor, J.T. et Short, J.M. (1993). Induction of hepatic mutations in lacI transgenic mice. Mutagenesis, 8:265-271.
Mitch, W.A. et Schreiber, I.M. (2008). Degradation of tertiary alkylamines during chlorination/chloramination: implications for formation of aldehydes, nitriles, halonitroalkanes, and nitrosamines. Environ. Sci. Technol., 42(13):4811-4817.
Mitch, W.A. et Sedlak, D.L. (2004). Characterization and fate of N-nitrosodimethylamine (NDMA) precursors during municipal wastewater treatment. Environ. Sci. Technol., 38(5):1445-1454.
Mitch, W.A., Sharp, J.O., Trussell, R.R., Valentine, R.L., Alvarez-Cohen, L. et Sedlak, D.L. (2003a). N-Nitrosodimethylamine (NDMA) as a drinking water contaminant: a review. Environ. Eng. Sci., 20(5):389-404.
Mitch, W.A., Gerecke, A.C. et Sedlak, D.L. (2003b). A N-nitrosodimethylamine (NDMA) precursor analysis for chlorination of water and wastewater. Water Res., 37:3733-3741.
Moiseev, G.E. et Benemanskii, V.V. (1975). Concerning the carcinogenic activity of small concentrations of nitrosodimethylamine during inhalation. Voprosy Onkologii, 21:107-109 [traduit pour la U.S. Environmental Protection Agency par Scientific Translation Service, Santa Barbara, California].
Moore, G. (1999). Communication personnelle. Division des affaires réglementaires et des innovations, Agence de réglementation de la lutte antiparasitaire, Santé Canada, Ottawa, Ontario [cité dans PISSC, 2002].
Morrison, V. et Ashby, J. (1994). Reconciliation of five negative and four positive reports of the activity of dimethylnitrosamine in the mouse bone marrow micronucleus assay. Mutagenesis, 9:361-365.
Najm, I. et Trussell, R.R. (2001). NDMA formation in water and wastewater. J. Am. Water Works Assoc., 93(2):92-99.
Nakatsuru, Y., Matsukama, S., Nemoto, N., Sugano, H., Sekiguchi, M. et Ishikawa, T. (1993). O6-Methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. Proc. Natl. Acad. Sci. U.S.A., 90:6468-6472.
Neal, S.B. et Probst, G.S. (1983). Chemically-induced sister-chromatid exchange in vivo in bone marrow of Chinese hamsters. An evaluation of 24 compounds. Mutat. Res., 113:33-43.
Neft, R.E. et Conner, M.K. (1989). Induction of sister chromatid exchange in multiple murine tissues in vivo by various methylating agents. Teratog. Carcinog. Mutagen., 9:219-237.
Nishie, K. (1983). Comparison of the effects of N-nitrosodimethylamine on pregnant and nonpregnant Holtzman rats. Food Chem. Toxicol., 21(4):453-462.
Odagiri, Y., Adachi, S., Katayama, H. et Takemoto, K. (1986). Detection of the cytogenetic effect of inhaled aerosols by the micronucleus test. Mutat. Res., 170:79-83.
OEHHA (2006). Public health goals for chemicals in drinking water-N-Nitrosodimethylamine. Pesticide and Environmental Toxicology Branch, Office of Environmental Health Hazard Assessment [en anglais seulement], California Environmental Protection Agency, Sacramento, California.
Oliver, J. (1979). Volatilization of some herbicide-related nitrosamines from soils. J. Environ. Qual., 8(4):596-601.
Pancholy, S.K. (1978). Formation of carcinogenic nitrosamines in soils. Soil Biol. Biochem., 10:27-32.
Parsa, I., Friedman, S. et Cleary, C.M. (1987). Visualization of O6-methylguanine in target cell nuclei of dimethylnitrosamine-treated human pancreas by a murine monoclonal antibody. Carcinogenesis, 8:839-846.
Pedal, I., Besserer, K., Goerttler, K., Heymer, B., Mittmeyer, H.J., Oehmichen, M. et Schmahl, D. (1982). Fatal nitrosamine poisoning. Arch. Toxicol., 50:101-112 [cité dans ATSDR, 1989].
Pegg, A.E. et Perry, W. (1981). Alkylation of nucleic acids and metabolism of small doses of dimethylnitrosamine in the rat. Cancer Res., 41:3128-3132.
Peto, R., Gray, R., Brantom, P. et Grasso, P. (1991a). Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study. Cancer Res., 51:6415-6451.
Peto, R., Gray, R., Brantom, P. et Grasso, P. (1991b). Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine. Cancer Res., 51:6452-6469.
Petzold, G.L. et Swenberg, J.A. (1978). Detection of DNA damage induced in vivo following exposure of rats to carcinogens. Cancer Res., 38:1589-1594.
Phillips, J.C., Lake, B.G., Heading, C.E., Gangolli, S.D. et Lloyd, A.G. (1975). Studies on the metabolism of dimethylnitrosamine in the rat. I. Effects of dose, route of administration and sex. Food Cosmet. Toxicol., 13:203-209.
PISSC (2002). N-Nitrosodimethylamine. Programme international sur la sécurité des substances chimiques, Organisation mondiale de la Santé, Genèeve (Concise International Chemical Assessment Document 38).
Pobel, D., Riboli, E., Cornée, J., Hémon, B. et Guyader, M. (1995). Nitrosamine, nitrate and nitrite in relation to gastric cancer: a case-control study in Marseille, France. Eur. J. Epidemiol., 11:67-73.
Pool, B.L., Brendler, S.Y., Liegibel, U.M., Tompa, A. et Schmezer, P. (1990). Employment of adult mammalian primary cells in toxicology: in vivo and in vitro genotoxic effects of environmentally significant N-nitrosodialkylamines in cells of the liver, lung, and kidney. Environ. Mol. Mutagen., 15:24-35.
Richardson, S.D. (2003). Disinfection by-products and other emerging contaminants in drinking water. Trends Anal. Chem., 22(10):666-684.
Risch, H.A., Jain, M., Choi, N.W., Fodor, J.G., Pfeiffer, C.J., Howe, G.R., Harrison, L.W., Craib, K.J.P. et Miller, A.B. (1985). Dietary factors and the incidence of cancer of the stomach. Am. J. Epidemiol., 122:947-957.
Robbiano, L., Mereto, E., Morando, A.M., Pastore, P. et Brambilla, G. (1997). An in vivo micronucleus assay for detecting the clastogenic effect in rat kidney cells. Mutat. Res., 390:51-57.
Rogers, M.A.M., Vaughan, T.L., Davis, S. et Thomas, D.B. (1995). Consumption of nitrate, nitrite, and nitrosodimethylamine and the risk of upper aerodigestive tract cancer. Cancer Epidemiol. Biomarkers Prev., 4:29-36.
Sacher, F., Schmidt, C.K., Lee, C. et Gunten, U.V. (2008). Strategies for minimizing nitrosamine formation during disinfection. Awwa Research Foundation, Denver, CO (Report No. 91209).
Santé Canada (1999). Supporting documentation (exposure) for N-nitrosodimethylamine. Section des substances d'intérêt prioritaire, Direction de l'hygiène du milieu, Santé Canada, Ottawa, Ontario (août 1999, ébauche).
Santé Canada (2008). Unit risks for NDMA. Note de service de M. Walker (chef, Division de la biostatistique, Direction générale de la santé environnementale et de la sécurité des consommateurs), 24 septembre 2008.
Sato, S., Taketomi, M. et Morita, T. (1992). Simplified mouse peripheral reticulocyte micronucleus test with dimethylnitrosamine. Mutat. Res., 278:103-107.
Sawada, S., Yamanaka, T., Yamatsu, K., Furihata, C. et Matsushima, T. (1991). Chromosome aberrations, micronuclei and sister-chromatid exchanges (SCEs) in rat liver induced in vivo by hepatocarcinogens including heterocyclic amines. Mutat. Res., 251:59-69.
Schmidt, C.K. et Brauch, H.-J. (2008). N,N-Dimethylsulfamide as precursor for N-nitrosodimethylamine (NDMA) formation upon ozonation and its fate during drinking water treatment. Environ. Sci. Technol., 42(17):6340-6346.
Schmidt, J.D. et Murphy, G.P. (1966). Urinary lactic dehydrogenase activity in rats with dimethylnitrosamine induced renal tumors. Invest. Urol., 4:57-63.
Schreiber, I.M. et Mitch, W.A. (2005). Influence of the order of reagent addition on NDMA formation during chloramination. Environ. Sci. Technol., 39(10):3811-3818.
Schreiber, I.M. et Mitch, W.A. (2006a). Nitrosamine formation pathway revisited: the importance of chloramines speciation and dissolved oxygen. Environ. Sci. Technol., 40(19):6007-6014.
Schreiber, I.M. et Mitch, W.A. (2006b). Occurrence and fate of nitrosamines and nitrosamine precursors in wastewater-impacted surface waters using boron as a conservative tracer. Environ. Sci. Technol., 40(10):3203-3210.
Schreiber, I.M. et Mitch, W.A. (2007). Enhanced nitrogenous disinfection byproduct formation near the breakpoint: implications for nitrification control. Environ. Sci. Technol., 41(20):7039-7046.
Sedlak, DL., Deeb, R., Hawley, E., Mitch, W., Durbin, T., Mowbray, S. et Carr, S. (2005). Sources and fate of nitrosodimethylamine and its precursors in municipal wastewater treatment plants. Water Environ. Res., 77(1):32-39.
Sen, N.P. et Baddoo, P.A. (1997). Trends in the levels of residual nitrite in Canadian cured meat products over the past 25 years. J. Agric. Food Chem., 45:4714-4718.
Sen, N.P. et Seaman, S. (1981). Volatile N-nitrosamimes in dried foods. J. Assoc. Off. Anal. Chem., 64(5):1238-1242.
Sen, N.P., Seaman, S.W., Bergeron, C. et Brousseau, R. (1996). Trends in the levels of N-nitrosodimethylamine in Canadian and imported beers. J. Agric. Food Chem., 44(6):1498-1501.
Sharpless, C.M. et Linden, K.G. (2003). Experimental and model comparisons of low- and medium-pressure Hg lamps for the direct and H2O2 assisted UV photodegradation of N-nitrosodimethylamine in simulated drinking water. Environ. Sci. Technol., 37(9):1933-1940.
Siddiqui, M. et Atasi, K. (2001). NDMA occurrence and formation-A review. Dans : Proceedings of the American Water Works Association Annual Conference, Washington, DC. American Water Works Association, Denver, Colorado.
Souliotis, V.L., Chhabra, S., Anderson, L.M. et Kyrtopoulos, S.A. (1995). Dosimetry of O6-methylguanine in rat DNA after low-dose, chronic exposure to N-nitrosodimethylamine (NDMA). Implications for the mechanism of NDMA hepatocarcinogenesis. Carcinogenesis, 16:2381-2387.
Spiegelhalder, B. et Preussmann, R. (1984). Contamination of toiletries and cosmetic products with volatile and non volatile N-nitroso carcinogens. J. Cancer Res. Clin. Oncol., 108:160-163.
Spiegelhalder, B., Eisenbrand, G. et Preussmann, R. (1982). Urinary excretion of N-nitrosamines in rats and humans. IARC Sci. Publ., 41:443-449.
Stehlik, G., Richter, O. et Altmann, H. (1982). Concentration of dimethylnitrosamine in the air of smoke-filled rooms. Ecotoxicol. Environ. Saf., 6:495-500.
Steinle-Darling, E., Zedda, M., Plumbee, M.H., Ridgway, H.F. et Reinhard, M. (2007). Evaluating the impacts of membrane type, coating, fouling, chemical properties and water chemistry on reverse osmosis rejection of seven nitrosoalkylamines, including NDMA. Water Res., 41:3959-3967.
Swenberg, J.A., Hoel, D.G. et Magee, P.N. (1991). Mechanistic and statistical insight into the large carcinogenesis bioassays on N-nitrosodiethylamine and N-nitrosodimethylamine. Cancer Res., 51:6409-6414.
Tanaka, A., Hisanaga, A., Inamasu, T., Hirata, M. et Ishinishi, N. (1988). A comparison of the carcinogenicity of N-nitrosodiethylamine and N-nitrosodimethylamine after intratracheal instillation into Syrian golden hamsters. Food Chem. Toxicol., 26:847-850.
Tate, R.L., III. et Alexander, M. (1975). Stability of nitrosamines in samples of lake water, soil, and sewage. J. Natl. Cancer Inst., 54:327-330.
Tates, A.D., Neuteboom, I., Hofker, M. et den Engelse, L. (1980). A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutat. Res., 74:11-20.
Tates, A.D., Neuteboom, I., de Vogel, N. et den Engelse, L. (1983). The induction of chromosomal damage in rat hepatocytes and lymphocytes. I. Time-dependent changes of the clastogenic effects of diethylnitrosamine, dimethylnitrosamine and ethyl methanesulfonate. Mutat. Res., 107:131-151.
Tates, A.D., Neuteboom, I., Rotteveel, A.H.M., de Vogel, N., Menkveld, G.J. et den Engelse, L. (1986). Persistence of preclastogenic damage in hepatocytes of rats exposed to ethylnitrosourea, diethylnitrosamine, dimethylnitrosamine and methyl methanesulfonate. Correlation with DNA O-alkylation. Carcinogenesis, 7:1053-1058.
Terao, K., Aikawa, T. et Kera, K. (1978). A synergistic effect of nitrosodimethylamine on sterigmatocystin carcinogenesis in rats. Food Cosmet. Toxicol., 16:591-596.
Terracini, B., Palestro, G., Gigliardi, M.R. et Montesano, R. (1966). Carcinogenicity of dimethylnitrosamine in Swiss mice. Br. J. Cancer, 20:871-876.
Thomas, R.G. (1982). Volatilization from water. Dans : W.J. Lyman, W.F. Reehl and D.H. Rosenblatt (eds.). Handbook of chemical property estimation methods. McGraw-Hill, New York, New York. p. 15-27.
Tinwell, H., Lefevre, P.A. et Ashby, J. (1994). Mutation studies with dimethyl nitrosoamine in young and old lac I transgenic mice. Mutat. Res., 307:501-508.
Tricker, A.R. et Preussmann, R. (1992). Volatile N-nitrosamines in mainstream cigarette smoke: occurrence and formation. Clin. Invest. 70:283-289.
Tricker, A.R., Ditrich, C. et Preussmann, R. (1991). N-Nitroso compounds in cigarette tobacco and their occurrence in the mainstream tobacco smoke. Carcinogenesis, 12(2):257-261.
Trzos, R.J., Petzold, G.L., Brunden, M.N. et Swenberg, J.A. (1978). The evaluation of sixteen carcinogens in the rat using the micronucleus test. Mutat. Res., 58:79-86.
Tugulea, A.M., Aranda-Rodriguez, R., Jay, B., Kubwabo, C. et Koudjonou, B. (2008). Emerging disinfection by-products (NDMA, MX) in Canadian drinking water - a survey of fifteen distribution systems. Travaux de la 13e Conférence nationale canadienne sur l'eau potable, octobre, Québec, Québec.
Tugulea, A.M., Aranda-Rodriguez, R., Kubwabo,C., Bérubé, D., Koudjonou, B., Giddings, M. et Lemieux, F., (2010). National Survey of Disinfection By-Products and Selected Emerging Contaminants in Canadian Drinking Water-First Year Results, Travaux de la 14e Conférence nationale canadienne sur l'eau potable, octobre - novembre, Saskatoon, Saskatchewan.
U.S. EPA (2004). Method 521: Determination of nitrosamines in drinking water by solid phase extraction and capillary column gas chromatography with large volume injection and chemical ionization tandem mass spectrometry (MS/MS). Version 1.0. U.S. Environmental Protection Agency, Washington, DC (EPA Document No. EPA/600/R-05/054).
van Rheenan, D.L. (1962). Determination of biogenic amines in faeces of normal dairy cattle. Nature, 193:170-171.
Wang, X., Suzuki, T., Itoh, T., Honma, M., Nishikawa, A., Furukawa, F., Takahashi, M., Hayashi, M., Kato, T. et Sofuni, T. (1998). Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice. Mutagenesis, 13:625-630.
Webster, R.P., Gawde, M.D. et Bhattacharya, R.K. (1996). Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats. Cancer Lett., 109:185-191.
Wilczak, A., Assadi-Rad, A., Lai, H.H., Hoover, L.L., Smith, J.F., Berger, R., Rodigari, F., Beland, J.W., Lazzelle, L.J., Kincannon, E.G., Baker, H. et Heaney, C.T. (2003). Formation of N-nitrosodimethylamine (NDMA) in chloraminated water coagulated with DADMAC cationic polymer. J. Am. Water Works Assoc., 95(9):94-107.
Wild, D. (1978). Cytogenetic effects in the mouse of 17 chemical mutagens and carcinogens evaluated by the micronucleus test. Mutat. Res., 56:319-327.
Yoo, J.-S.H., Ning, S.M., Patten, C.J. et Yang, C.S. (1987). Metabolism and activation of N-nitrosodimethylamine by hamster and rat microsomes: comparative study with weanling and adult animals. Cancer Res., 47:992-998.
Zhao,Y-Y., Boyd, J.M., Woodbeck, M., Andrews, R.C., Qin, F., Hrudey, S.E. et Li, X. F. (2008). Formation of N-Nitrosamines from eleven disinfection treatments of seven different surface waters. Environ. Sci. Technol., 42(13):4857-4862.
Zhu, J.H., Yan, D., Xai, J.R., Ma, L.L. et Shen, B. (2001). Attempt to adsorb N-nitrosamines in solution by use of zeolites. Water Res., 44(5):949-956.
Annexe A : Liste des acronymes
2,4-D
acide 2,4-dichlorophénoxyacétique
A
adénine
ADN
acide désoxyribonucléique
ANSI
American National Standards Institute
ARN
acide ribonucléique
C
cytosine
CCN
Conseil canadien des normes
CL
50
concentration létale médiane
CMA
concentration maximale acceptable
CYP
cytochrome P450
DJA
dose journalière admissible
DL
50
dose létale médiane
DMA
diméthylamine
DT
05
dose tumorigène
05; dose qui entraîne une augmentation de 5 % de l'incidence des tumeurs par rapport au niveau de fond
DTI
05
limite inférieure de l'intervalle de confiance à 95 % de la DT
05
EPA
Environmental Protection Agency
F
air-eau
concentration air-eau de NDMA
G
guanine
K
aw
constante de la loi de Henry
K
oe
coefficient de partage n-octanol/eau
K
p
coefficient de perméabilité cutanée
LCI
limite inférieure de l'intervalle de confiance
Leq
litre équivalent
LOEC
concentration minimale avec effet observé
MCPA
acide (4-chloro-2-méthylphénoxy) acétique
MON
matières organiques naturelles
NDMA
N-nitrosodiméthylamine
NSF
NSF International
OI
osmose inverse
OMS
Organisation mondiale de la Santé
p.c.
poids corporel
POA
procédé d'oxydation avancé
ppm
partie par million
S9
homogénat de foie obtenu par centrifugation à 9 000 g
