Evidence brief on attitudes and acceptance of COVID-19 booster doses
January 2022
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Table of contents
Introduction
What is the evidence on the knowledge, attitudes, and behaviors related to booster (third/additional) doses of the COVID-19 vaccine in Canada, Australia, New Zealand, UK, and the US?
Canada has one of the highest vaccination rates of the primary series (2 doses) of COVID-19 in the world, with 82.8% of those over the age of 5 fully vaccinatedFootnote 1. The UK and Australia approved COVID-19 booster doses for those over 18 years old in September and October 2021, respectivelyFootnote 2Footnote 3. In November 2021 booster doses of COVID-19 vaccines were approved for those over 18 in Canada, New Zealand, and the USFootnote 4Footnote 5Footnote 6.
Understanding the facilitators, barriers, and hesitancy to accept or refuse COVID-19 booster doses among those who have already accepted two doses is important for encouraging recommended vaccination among both partially vaccinated and unvaccinated populations in the face of waning immunity and more transmissible variants. This evidence brief summarizes literature on the intention to accept a booster dose of vaccine among the general population and factors associated with the intention to accept or reject additional doses. The focus of this evidence brief is on the Five Eyes countries (Canada, Australia, New Zealand, UK, and US) as these countries tend to have similar trends. This brief contains literature up to January 31, 2022.
Key points
There were 14 studies identified that evaluated attitudes and acceptance of a COVID-19 booster dose in Canada (n=4), UK (n=3), US (n=5), Canada and US (n=1) and globally (13 countries including Australia, Canada, UK, and US, n=1) (Table 1). Ten of the studies were conducted since the approval of the COVID-19 booster dose in their respective countries and the remaining 4 were conducted prior to the approvals in early to mid-2021.
- The most recent Canadian studies from January 2022 report those who intend to receive a COVID-19 vaccine booster currently varies between 70-77% in the general publicFootnote 7Footnote 8. Three studies conducted between August-December 2021 show a range of intention to receive a booster between 62-89%Footnote 9Footnote 10Footnote 1. Intention to accept a booster was highest in Atlantic Canada, Quebec, and Ontario and lowest in British Columbia and the PrairiesFootnote 10.
- Intentions to accept COVID-19 booster doses have decreased between late 2021 and early 2022 in Canada and the UKFootnote 8Footnote 11Footnote 12.
- A longitudinal study in the UK showed that intention to receive a COVID-19 vaccine booster remained steady from 88-95% between August and December 2021 but decreased to 72% in January 2022Footnote 12. This study also demonstrated that 75% were likely to get a booster dose for COVID-19 at the same time as their flu shot, which has steadily decreased since Aug 2021Footnote 12.
- The three most recent studies in the US conducted between August and November 2021 revealed that 79-81% of the general population and 96.2% of university students/staff intended to receive a boosterFootnote 11Footnote 13Footnote 14.
Barriers and facilitators to accepting a COVID-19 booster were similar to accepting first and second doses of the vaccineFootnote 15.
- Three studies showed that hesitancy about initial COVID-19 vaccination may be a strong predictor for hesitancy about booster doses of the vaccineFootnote 16Footnote 17Footnote 18.
- Compared to White respondents, Black respondents were less likely (OR 0.67, p<0.01) and Asian respondents were more likely (OR 2.45, 95%CI: 1.46-4.18) to accept a COVID-19 boosterFootnote 14Footnote 19.
- The most common factors positively associated with intention to receive a booster were older ageFootnote 7Footnote 8Footnote 9Footnote 10Footnote 12Footnote 16Footnote 17Footnote 19Footnote 20, higher educationFootnote 7Footnote 16Footnote 17Footnote 19, having longer-term physical health conditionsFootnote 12Footnote 16Footnote 17, being a past voter for the Liberal/Democrat partiesFootnote 9Footnote 16Footnote 19, living in a larger more populated areaFootnote 7Footnote 19, higher trust in science and COVID-19 informationFootnote 7Footnote 19, and male genderFootnote 10Footnote 16.
- The main concerns for those unlikely to accept a COVID-19 booster vaccine includes concern about short and long term side-effectsFootnote 8Footnote 12Footnote 13Footnote 20, belief that a booster dose would not offer extra protectionFootnote 12Footnote 20, and the belief that the first and second dose would keep them safeFootnote 12Footnote 20.
COVID-19 booster attitudes in the general public were explored in nine studies (Table 1). Six of the studies were conducted since the approval of booster doses in their respective countries.
- Across Canada, UK, and US, 63-89% believed that getting a booster dose (including receiving additional booster doses of the vaccine when necessary) was effective at providing protection from the virus or important to slowing the spread of virusFootnote 8Footnote 12Footnote 21.
- In January 2022, those who had received three doses in Canada believed the current restrictions were appropriate or that it was not yet time to reduce restrictions. The desire to keep restrictions was higher for those who had been vaccinated, particularly those with third doses, compared to those who had not been vaccinatedFootnote 22.
- While both unvaccinated and third dose recipients in Canada believed they will be exposed to and infected by Omicron no matter what they do (53% vs 54%), third dose recipients were more likely than unvaccinated to believe that if they caught COVID-19 it could be severe/deadly (17% vs 7%)Footnote 22Footnote 23.
- In a UK study in January 2022, 75% stated they would be likely to get a booster dose for COVID-19 at the same time as their flu shot. This has steadily decreased from 85% since August 2021Footnote 12.
Overview of the evidence
Fourteen studies evaluating the attitudes of the general public toward booster doses (third doses) of COVID-19 vaccine were identified and included in this review. Of these, two are preprints and eight are reports which have not completed the peer-review process. The publications reporting on third dose vaccine attitudes are all observational studies (e.g., cross-sectional study using an online survey).
A formal risk of bias evaluation was not conducted. Across observational studies the reliability of the outcome is based on obtaining a representative sample of the target population that is sufficiently large to obtain a representative spectrum of results. Studies frequently did not demonstrate the representativeness of their samples to the target population in both grey literature or government reports published online (not indexed), preprints, and published journal articles. Longitudinal studies where a population was sampled more than one time to monitor changes in vaccine intentions and attitudes over time were the strongest observational study design identified. Most observational studies were cross-sectional online surveys at a single point in time. These study designs are at moderate/high risk of bias and thus, are considered medium-low quality depending on the sample size and whether the sample represents the target population as well as how well the survey tool can measure the outcome(s) of interest (e.g., was it informed by formative research, validated and pretested prior to implementation). For most of the included studies the outcomes are self-reported, which can be biased by response and social desirability biases. Other biases considered in these studies include response rate and missing data. While there are many studies that show similar trends, the conclusions could change with additional research, larger sample size, different sampling strategies, data collection tools, and progression through the pandemic.
A key knowledge gap in this research are studies that address booster dose intentions and reasons for hesitancy and refusal rates in high-risk and underserved populations, and studies which identify factors that would encourage individuals to receive a booster dose. The majority of studies used online surveys, and to a lesser extent telephone surveys, which may limit participation from segments of population due to lack of access. Given the variable access to booster doses, understanding intention to vaccinate and hesitancy for accepting a booster dose remains crucial to encouraging vaccination in the face of waning immunity and more transmissible variants.
COVID-19 booster intentions and attitudes of the general public
Attitudes and acceptance of a booster dose of the COVID-19 vaccine in the general public were explored in 14 studies. There were four studies specific to Canada, three in the UK, five in the US, one that looked at both Canada and the US, and one global study that included Australia, Canada, UK, and US. High level points from all studies are listed below followed by more detailed outcomes (Table 1).
Intention to accept COVID-19 boosters decreased between late 2021 and early 2022Footnote 8Footnote 11Footnote 12.
- The most recent studies from January 2022 report those who intend to receive a COVID-19 vaccine booster currently varies between 70-77% in the Canadian general publicFootnote 7Footnote 8. Three studies conducted between August-December 2021 show a range of intention to receive a booster between 62-89%Footnote 9Footnote 10Footnote 11. In a December 2021 survey, intention to accept a booster was highest in Atlantic Canada (93.3%), Quebec (90.1%), and Ontario (90%), followed by British Columbia (85.2%) and the Prairies (82.5%)Footnote 10.
- In a global survey of 13 countries conducted in August 2021, the highest intentions to get a booster vaccine if it were available to respondents that day in the countries relevant to this review were in Australia (82%), UK (82%), US (81%), and Canada (77%)Footnote 11.
- A longitudinal study in the UK showed that intention to receive a COVID-19 vaccine booster remained steady from 88-95% between August-December 2021Footnote 12. This decreased to 72% in the most recent study conducted in January 2022Footnote 12. This study also reported that 75% were likely to get a booster dose for COVID-19 at the same time as their flu shot, which has steadily decreased since Aug 2021Footnote 12 .
- The two most recent studies in the US conducted between August and September 2021 revealed that 79-81% of the general population intended to receive a boosterFootnote 11Footnote 13. In California between August and November 2021, 96.2% of staff and students from a university were willing to receive a COVID-19 booster at least once per year, and 64% were willing to get boosters as often as necessaryFootnote 14.
- A study conducted from May to June 2021 in the US reported that the overall acceptance for a combination influenza-COVID-19 vaccine was 50%. This was slightly higher than a stand-alone COVID-19 booster (45%) and lower than a stand-alone influenza vaccine (58%)Footnote 19.
Barriers and facilitators to accepting a COVID-19 booster were similar to accepting first and second doses of the vaccineFootnote 15.
- Three studies showed that hesitancy about initial COVID-19 vaccination may be a strong predictor for hesitancy about booster doses of the vaccineFootnote 16Footnote 17.
- In the UK, those who were initially uncertain about receiving a vaccine (first and second doses) were more likely to be uncertain or unwilling to receive a booster (uncertain: RR 4.92, 95%CI: 2.98-8.11; unwilling: RR 5.29, 95%CI: 3.07- 9.09) compared to those who were initially willing. Initial unwillingness about receiving a vaccine (first and second dose) was also associated with a higher risk of booster uncertainty and unwillingness (uncertain: RR 6.40, 95%CI: 3.94-10.41; unwilling: RR 11.29, 95%CI: 6.79-18.78)Footnote 17.
- In the US, those who had already received a primary dose of COVID-19 vaccine were more likely to accept booster doses (OR 3.32, 95%CI: 2.20–5.01)Footnote 16. A second study showed that those who were booster hesitant were more likely to be unvaccinated (unvaccinated: 62.6%, 95% CI: 59.2–65.9% vs. vaccinated 12.9%, 95% CI: 11.1–14.8%; p < 0.001)Footnote 16.
- Compared to White respondents, Black respondents were less likely to accept a COVID-19 booster (OR 0.67, p<0.01)Footnote 19 and Asian respondents were more likely to accept a COVID-19 booster than White respondents (OR 2.45, 95%CI: 1.46-4.18)Footnote 14.
- The most common factors positively associated with intention to receive a booster were older ageFootnote 7Footnote 8Footnote 9Footnote 10Footnote 12Footnote 16Footnote 17Footnote 19Footnote 20, higher educationFootnote 7Footnote 16Footnote 17Footnote 19, having longer-term physical health conditionsFootnote 12Footnote 16Footnote 17, being a past voter for the Liberal/Democrat partiesFootnote 9Footnote 16Footnote 19, living in a larger more populated areaFootnote 7Footnote 19, higher trust in science and COVID-19 informationFootnote 14Footnote 16, and male genderFootnote 10Footnote 16.
- The main reasons for being unlikely to accept a COVID-19 booster vaccine includes concern about short and long term side-effectsFootnote 8Footnote 12Footnote 13Footnote 20, belief that a booster dose would not offer extra protectionFootnote 12Footnote 20, and belief that the first and second dose would keep them safeFootnote 12Footnote 20.
- In a January 2022 study, 56% of Canadians were concerned about long term side-effects from a third dose and this concern was more prevalent among younger respondents compared to older respondents (66% among those aged 18-34, 57% in those aged 35-54, and 47% among those aged 55+)Footnote 8.
- In the UK, 63% reported that no vaccine incentives would increase their motivation to get a third dose. Among those who could be motivated, the top motivator was helping life get back to normal (34%)Footnote 20.
Attitudes towards COVID-19 boosters
- Across Canada, UK, and US, 63-89% believed that getting a booster dose (including receiving additional boosted doses of the vaccine when necessary) was effective at providing protection from the virus or important to slowing the spread of virusFootnote 8Footnote 12Footnote 21.
- In August 2021, 69% of Canadians, 68% of Americans, 70% of Australians, and 77% of those in the UK agreed that they will need a booster at least every year for COVID-19Footnote 11. Acceptance for a hypothetical yearly booster was lower in those who were vaccine-hesitantFootnote 24.
- In January 2022, those who had received three doses in Canada believed that current restrictions were appropriate or that it was not yet time to reduce restrictions. The desire to keep restrictions was higher for those who had been vaccinated, particularly those with third doses, compared to those who had not been vaccinatedFootnote 22.
- While both unvaccinated and third dose recipients in Canada believed they will be exposed to and infected by Omicron no matter what they do (53% vs 54%), third dose recipients were more likely than unvaccinated to believe that if they caught COVID-19 it could be severe/deadly (17% vs 7%)Footnote 22Footnote 23.
- In Canada, 63% would be in favor of sending vaccines to developing countries before offering third doses to CanadiansFootnote 7.
- In a UK study in January 2022, 75% would be likely to get a booster dose for COVID-19 at the same time as their flu shot. This has steadily decreased from 85% since August 2021Footnote 12.
Methods
Publications and Preprints
A daily scan of the literature (published and pre-published) is conducted by the Knowledge Synthesis team in the Emerging Science Group, Public Health Agency of Canada. The scan has compiled COVID-19 literature since the beginning of the outbreak and is updated daily. Searches to retrieve relevant COVID-19 literature are conducted in Pubmed, Scopus, BioRxiv, MedRxiv, ArXiv, SSRN, Research Square, and and cross-referenced with the COVID-19 information centers run by Lancet, BMJ, Elsevier, Nature and Wiley. The cumulative scan results are maintained in a Refworks database and an excel list that can be searched. Targeted keyword searching is conducted within these databases to identify relevant citations on COVID-19 and SARS-COV-2. Search terms used included: (“vaccin*” or “immuni*”) and (“third dose*” or “booster”). This review contains research published up to January 31, 2022.
Grey Literature
A grey literature search was conducted to compliment the database search. The grey literature search focused on targeted governmental and academic institutions. A detailed list of websites searched is available upon request. The grey literature search was last updated on January 31, 2022.
Each potentially relevant reference was examined to confirm it had relevant data and relevant data was extracted into the review.
Acknowledgements
Prepared by: Tricia Corrin and Austyn Baumeister, National Microbiology Laboratory Emerging Science Group, Public Health Agency of Canada.
Editorial review, science to policy review, peer-review by a subject matter expert and knowledge mobilization of this document was coordinated by the Office of the Chief Science Officer: ocsoevidence-bcscdonneesprobantes@phac-aspc.gc.ca
Evidence tables
Table 1. Evidence of attitudes and acceptance of a booster dose of the COVID-19 vaccine in the general public (n=14)
Study | Method | Outcomes |
Canada (n=5) | ||
INSPQ (2021)Footnote 7Footnote 25 Longitudinal study Canada |
Analysis of the acceptability of vaccination against COVID-19 was evaluated using an online survey of adults and HCWs in Quebec. Number of participants was not clearly stated (~3300 each collection period). Articles in French. There were multiple collection periods: |
|
Ipsos (2022)Footnote 8 Cross-sectional study Canada |
An online survey of 1001 adults across Canada (18+) were recruited from the Ipsos I-say panel as well as non-panel sources to understand vaccination in the time of Omicron. |
|
Angus Reid (2021)Footnote 9Footnote 22Footnote 23 Longitudinal study Canada |
Intentions for getting a third dose of the COVID-19 vaccine were analyzed in a sample of the general population using an online survey across a representative randomized sample who are members of the Angus Reid Forum. Sep 29 – Oct 3, 2021 (n=5011) |
Jan 2022
Sep-Oct 2021
|
Leger (2021)Footnote 21Footnote 26Footnote 27 Longitudinal study Canada & US |
An online survey of Canadian and American adults (18+) was conducted to evaluate vaccine perceptions and intentions to vaccinate. Canadian data is summarized here and data from the US is found in the US section. Aug 2021, 1,515 Canadians, 1,005 Americans |
Jan 2022
Dec 2021
Aug 2021
|
Nanos (2021)Footnote 10Footnote 28 Longitudinal study Canada |
A hybrid telephone and online survey of adults (18+) across Canada was conducted to evaluate interest in receiving a third dose of the COVID-19 vaccine. Sep-Oct 2021 (n=1017) |
Dec 2021
Sep-Oct 2021
|
United Kingdom (n=3) |
||
Paul (2022)Footnote 17 Cross-sectional study UK |
Factors associated with COVID-19 booster vaccine intentions were evaluated in 22,139 fully vaccinated (two doses) adults in the UK. |
|
Office for National Statistics (2021)Footnote 20 Cross-sectional study UK |
In this COVID-19 Vaccine Opinions Study (VOS) respondents who previously reported being vaccine hesitant in the Opinions and Lifestyle Survey (OPN) and consented to follow-up (n=2480) were asked about motivations and barriers to vaccination. |
|
Office for National Statistics (2021)Footnote 12Footnote 18Footnote 29Footnote 30Footnote 31Footnote 32Footnote 33Footnote 34Footnote 35Footnote 36Footnote 37Footnote 38Footnote 39Footnote 40 Longitudinal study UK |
Intention to accept a booster dose of the COVID-19 vaccine was collected as part of the online Opinions and Lifestyle Survey. 2021 |
January 2022
December 2021
November
October
September
August
July - August
|
US (n=6) | ||
Leger (2021)Footnote 21Footnote 26Footnote 27 Longitudinal study Canada & US |
An online survey of Canadian and American adults (18+) was conducted to evaluate vaccine perceptions and intentions to vaccinate. Data from the US is summarized here and Canadian data is in the Canada section. Aug 2021, 1,515 Canadians, 1,005 Americans |
January 2022
December 2021
|
Lee (2021)Footnote 14 Cross-sectional study US |
COVID-19 booster vaccine attitudes and behaviors among 3,668 university students and staff at the University of Southern California were evaluated using an online survey. Willingness to receive a booster was coded as “unwilling” (never) and “willing” (any response other than “never”). |
|
Hahn (2022)Footnote 13 Longitudinal study US |
Residents from remote communities in Alaska participated in three online surveys to evaluate residents’ early vaccine acceptance, vaccine uptake and motivations, risk perceptions and knowledge about COVID-19 vaccines, and likelihood of getting a booster vaccine. Survey 1: Nov-Dec 2020 (n=107) Only results on acceptability of a booster vaccine are captured from survey 3. |
|
Yadete (2022)Footnote 16 Cross-sectional study US |
COVID-19 vaccine booster hesitancy and its associated factors were evaluated using an online survey. The survey included 2,138 adults from across the US. |
|
Lennon (2022)Footnote 19 Cross-sectional study US |
Attitudes towards COVID-19 booster, influenza, and a hypothetical combination influenza-COVID-19 booster vaccines were evaluated using an online survey of 12,887 adults from across the US. |
|
Pal (2021)Footnote 24 Cross-sectional study US |
An online survey was used to assess vaccine hesitancy and attitudes toward a potential additional booster dose of COVID-19 vaccines among 1,358 healthcare workers (HCWs) across the US. Those who had received both doses or were planning to receive both doses of the vaccine were labelled as the vaccine non-hesitant group and those who did not accept either dose or were waiting or unsure, were labelled as the vaccine-hesitant group. |
|
Global (n=1) | ||
Ipsos (2021)Footnote 11 Cross-sectional study Global (Canada, Australia, Brazil, China, France, Germany, Italy, Japan, Mexico, Russia, Spain, US, UK) |
Global attitudes towards COVID-19 booster doses of vaccine were evaluated across 13 countries using an online survey. Willingness to receive a third dose was measured in 1,000 adults aged 18-74 from Canada and the US, 1,000 adults aged 16-74 from the UK, France, Germany, and Japan, and 500 adults aged 16-74 in Australia, Brazil, China, Italy, Mexico, Russia, and Spain. Results specific to Australia, Canada, UK, and US. |
Canada
US
Australia
UK
|
Abbreviations: CI, confidence interval; HCW, healthcare worker; OR, odds ratio; RR, risk ratio. |
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Office for National Statistics. Opinions and Lifestyle Survey (August 25 - September 5, 2021). URL: https://www.ons.gov.uk/file?uri=/peoplepopulationandcommunity/healthandsocialcare/healthandwellbeing/datasets/coronavirusandthesocialimpactsongreatbritaindata/current/previous/v75/referencetables100921.xlsx
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Office for National Statistics. Opinions and Lifestyle Survey (September 8 - September 19, 2021). 2021.URL: https://www.ons.gov.uk/file?uri=/peoplepopulationandcommunity/healthandsocialcare/healthandwellbeing/datasets/coronavirusandthesocialimpactsongreatbritaindata/current/previous/v76/referencetables240921.xlsx
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Office for National Statistics. Opinions and Lifestyle Survey (August 18 - August 22, 2021). 2021.URL: https://www.ons.gov.uk/file?uri=/peoplepopulationandcommunity/healthandsocialcare/healthandwellbeing/datasets/coronavirusandthesocialimpactsongreatbritaindata/current/previous/v73/referencetables200821.xlsx
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Office for National Statistics. Opinions and Lifestyle Survey (September 22 - October 3, 2021). 2021.URL: https://www.ons.gov.uk/file?uri=/peoplepopulationandcommunity/healthandsocialcare/healthandwellbeing/datasets/coronavirusandthesocialimpactsongreatbritaindata/current/previous/v77/referencetables081021.xlsx
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Office for National Statistics. Opinions and Lifestyle Survey (December 1 - December 12, 2021). 2021.URL: https://www.ons.gov.uk/file?uri=%2fpeoplepopulationandcommunity%2fhealthandsocialcare%2fhealthandwellbeing%2fdatasets%2fcoronavirusandthesocialimpactsongreatbritaindata%2f17december2021/referencetables171221.xlsx
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Office for National Statistics. Opinions and Lifestyle Survey (March 2020 - December 2021). 2021.URL: https://www.ons.gov.uk/file?uri=%2fpeoplepopulationandcommunity%2fhealthandsocialcare%2fhealthandwellbeing%2fdatasets%2fcoronavirusandthesocialimpactsongreatbritaindata%2f23december2021/opnsocialimpacts23dec.xlsx
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