Updated pesticide chemistry verification process and work plan

Pest Management Regulatory Agency
4 October 2024

The Pest Management Regulatory Agency (PMRA) is modernizing its pesticide review process through the implementation of a continuous oversight model. As part of this process modernization effort, the PMRA’s approach for verifying product chemistry information of technical grade active ingredient products is updated.

Verifying product chemistry as part of continuous oversight is an important component for ensuring that health and environmental risk assessments are relying on the best available chemistry information. This initiative will contribute to improved monitoring of pesticide active ingredients to confirm they are being manufactured consistent with approved specifications and methods. It will also ensure that the PMRA’s chemistry review is up-to-date when an active undergoes re-evaluation, resulting in more timely decisions.

To provide registrants with advance notice of when their active ingredients will be subject to chemistry verification and to keep other interested stakeholders informed, the PMRA is maintaining a transparent five-year chemistry verification work plan, which will be updated annually.^{Footnote 1}

Through this updated process, chemistry verification for each active ingredient is expected to occur at least every 10 years, with the flexibility to require chemistry verification sooner when warranted. For example:

• When actives or sources are known to contain impurities or contaminants of health or environmental concern;
• When the PMRA becomes aware of a potential issue that requires further assessment;
• When there is a history of discrepancies in specifications for certain actives or sources.

Registrants will be requested to submit listed chemistry information regarding their active ingredient, including quality control data, description of the current manufacturing process and up-to-date product specification form. When needed, the PMRA will request additional GLP-compliant chemistry batch data and/or impurity of concern data to support continued registration.

If the chemistry verification determines that the product composition is not within approved specifications, or the manufacturing process has changed without proper reporting, Health Canada may consider appropriate compliance and enforcement actions.

Additional details on the process are provided in the “Memorandum to Registrants: Verifying Chemistry of Registered Technical Grade Active Ingredients and Integrated System Products”.

Below is the five-year chemistry verification work plan for 1 April 2024 to 31 March 2029.

Active ingredients subject to chemistry verification in 2024-2025

• Acibenzolar-s-methyl
• 3-(Trimethoxysilyl)propyldimethyloctadecyl ammonium chloride
• 3-(Trihydroxysilyl)propyldimethyloctadecyl ammonium chloride
• Butoxypolypropylene glycol
• Citric acid
• Castor oil
• Dichlorprop-p (present as dimethylamine salt)
• Dichlorprop-p
• Dichlorprop p-isomer (present as 2-ethylhexyl ester)
• 1,4-Dimethylnaphthalene
• Diodofon
• Diquat
• Dried eggs
• Fish meal mixture
• Fish oil mixture
• Flonicamid
• Garlic oil
• Garlic powder
• Hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine
• Imazethapyr
• 3-Iodo-2-propynyl butyl carbamate
• Iron (present as FeHEDTA)
• d-Limonene
• Meat meal mixture
• Mesosulfuron-methyl
• Metconazole
• Metrafenone
• Naphthalene
• Oxalic acid dihydrate
• Paradichlorobenzene
• Saponins of Chenopodium quinoa (food grade)
• Sodium fluoride
• Tefluthrin
• Tembotrione
• Thiabendazole
• Thymol
• Tralkoxydim
• Wintergreen oil
• Gibberellic acid
• Gibberellins A4 and A7^{Footnote 2}
• Calcium hypochlorite^{Footnote 2}
• Putrescent whole egg solids^{Footnote 2}
• Sodium chloride
• Sodium hypochlorite^{Footnote 2}

Active ingredients subject to chemistry verification in 2025-2026

• 1,2-Benzisothiazolin-3-one, BIT
• 6-Benzylaminopurine (or: 6-benzyladenine)
• Bromoxynil
• Chloridazon
• 2,4-D
• 2,4-D (present as amine salts: dimethylamine salt, diethanolamine salt, or other amine salts)
• 2,4-D (present as low volatile esters)
• 2,4-D (present as choline salt)
• Dicamba (present as acid, ester, salt)
• Dodine
• Ethametsulfuron-methyl
• Imazapyr
• Mandipropamid
• MCPA (present as acid)
• MCPA (present as amine salts: diethanolamine, dimethylamine, or mixed amines)
• MCPA (present as esters)
• MCPA (present as potassium salt or as sodium salt)
• Mineral oil
• Nicosulfuron
• Oxirane derivatives (50% minimum)
• Pendimethalin
• 2-Phenylphenol
• 2-Phenylphenol (present as potassium salt)
• 2-Phenylphenol (present as sodium salt)
• Propylene glycol
• Rimsulfuron
• Sodium chlorate
• Sodium chlorite
• Spirotetramat
• Sulfentrazone
• Tetrakis (hydroxymethyl) phosphonium sulfate (THPS)

Active ingredients subject to chemistry verification in 2026-2027

• n-Alkyl(25% c12, 60% c14, 15% c16)dimethylbenzylammonium chloride
• Alkyl(40% c12, 50% c14, 10% c16)dimethylbenzylammonium chloride
• n-Alkyl(68% c12, 32% c14)dimethyl ethylbenzyl ammonium chloride
• n-Alkyl (60% c14, 30% c16, 5% c12, 5% c18)dimethyl benzyl ammonium chloride
• n-Alkyl(40% c12, 50% c14, 10% c16)dimethylbenzylammonium saccharinate
• n-Alkyl(67% c12, 25% c14, 7% c16, 1% c18)dimethylbenzylammonium chloride
• Diisobutylphenoxyethoxyethyldimethylbenzylammonium chloride
• n-Dialkyl(5% c12, 60% c14, 30% c16, 5% c18)methylbenzylammonium chloride
• 1-Alkyl(c6-c18)-1,3-propanediamine
• N-Alkyl-1,3-propanediamine acetate
• N-coco-alkyl trimethylene diamines (present as monobenzoate salt)
• 1,3-bis(hydroxymethyl)-5,5-dimethylhydantoin, hydroxymethyl-5,5-dimethylhydantoin
• Ammonium soap of fatty acid
• Bifenthrin
• Carbathiin
• Chlorthal (present as dimethyl ester)
• Cloransulam-methyl
• Chlormequat chloride
• Codlelure
• Cyprosulfamide
• n-Decanol
• Desmedipham
• Diazinon
• Didecyldimethylammonium chloride
• Dimethenamid-p
• Dioctyldimethylammonium chloride
• Dithiopyr
• Flumioxazin
• Formetanate hydrochloride
• Glutaraldehyde
• Hexazinone
• Imazamethabenz-methyl
• Lime sulphur
• Mono- and dipotassium phosphite
• Metsulfuron-methyl
• Metaldehyde
• Maleic hydrazide
• Naphthylacetic acid
• Oxydiethylene bis(alkyl dimethyl ammonium chloride)
• 1-Octanol
• r-(-)-1-Octen-3-ol
• Octyldecyldimethylammonium chloride
• Oxycarboxin
• Ozone
• Picloram (present as acid)
• Picloram (present as amine salts)
• Picloram (present as potassium salt)
• Propyzamide
• Phenmedipham
• Saflufenacil
• Simazine plus related active triazines
• Streptomycin
• Thiencarbazone-methyl
• Thifensulfuron-methyl
• Tribenuron-methyl
• Trifluralin
• Available chlorine, present as sodium hypochlorite^{Footnote 3}

Active ingredients subject to chemistry verification in 2027-2028

• Ancymidol
• Arsenic acid
• Available chlorine present as 1-bromo-3-chloro-5,5-dimethylhydantoin and related hydantoins
• Available bromine present as 1-bromo-3-chloro-5,5-dimethylhydantoin and related hydantoins
• Available chlorine present as 1-bromo-3-chloro-5,5-dimethylhydantoin, 1,3-dichloro-5,5-dimethylhydantoin, 1,3-dichloro-5-ethyl-5-methylhydantoin and related hydantoins
• Available chlorine present as 1,3-dichloro-5,5-dimethylhydantoin and 1,3- dichloro-5-ethyl-5-methylhydantoin
• Clopyralid (present as acid, or as salts)
• Copper (present as copper naphthenate)
• Copper (present as copper 8-quinolinolate)
• Copper, present as basic copper carbonate
• Basic copper sulfate
• Bromethalin
• Chlorpropham
• Chlorsulfuron
• Chromic acid
• Citronella oil
• Clomazoneb
• Copper (present as cuprous oxide, cupric oxide and metallic copper)
• Copper (present as cupric oxide)
• Creosote
• Cyazofamid
• Diflubenzuron
• Diphacinone (present in free form or as sodium salt)
• Diphenylamine
• Dried blood
• Endothal or endothall
• EPTC
• Fluopicolide
• Formaldehyde
• Formic acid
• Icaridin
• Indaziflam
• 3-Methyl-2-cyclohexen-1-one
• Methyl nonyl ketone
• Metofluthrin
• Oriental mustard seed meal
• Paraformaldehyde
• Penflufen
• Penthiopyrad
• Propiconazole
• Verbenone
• Extract of Reynoutria sachalinensis
• Zinc as elemental (present as zinc naphthenate)
• Zinc (present as zinc oxide)
• Available chlorine, present as calcium hypochlorite^{Footnote 4}

Active ingredients subject to chemistry verification in 2028-2029

• Abamectin
• Acequinocyl
• Ametoctradin
• Aminopyralid
• Ammonia (present as ammonium sulfate)
• Ammonium bromide
• Atrazine (plus related active triazines)
• Azoxystrobin
• Bifenazate
• Bensulide
• Benzyl benzoate
• Bromacil (present in free form, as dimethylamine salt, or as lithium salt)
• Liquid carbon dioxide
• Cloquintocet-mexyl
• Chlorfenapyr
• Cyantraniliprole
• Denatonium benzoate
• 3-Decen-2-one
• 1,2-Dibromo-2,4-dicyanobutane
• Difethialone
• Dodecylguanidine hydrochloride
• Ethalfluralin
• (E,Z)-2,13-octadecadien-1-yl acetate
• Fenoxaprop-p-ethyl
• Ferric sodium ethylenediaminetetraacetic acid
• Fluazifop-p-butyl and s-isomer
• Fluopyram
• Fluoxastrobin
• Fluxapyroxad
• Fosetyl-al
• Garlic juice
• Glufosinate-ammonium
• Halosulfuron (present as methyl ester)
• Hydramethylnon
• Imiprothrin
• Kasugamycin hydrochloride hydrate
• Malathion
• MCPB
• MCPB (present as sodium salt)
• Mesotrione
• Metalaxyl-m and S-isomer
• 1-Methylcyclopropene
• Metribuzin
• Mono- and dibasic sodium, potassium, and ammonium phosphites
• Myclobutanil
• Naled
• Natamycin
• Niclosamide
• Octenol
• Oil of lemon eucalyptus, hydrated, cyclized
• d-Phenothrin
• Potassium dimethyldithiocarbamate
• Poly[oxyethylene(dimethyliminio)ethylene(dimethyliminio)ethylene dichloride]
• Picoxystrobin
• Pyroxasulfone
• Quinclorac (present as dimethylamine salt)
• Sedaxane
• S-metolachlor and R-enantiomer
• Sulfoxaflor
• Tea tree oil
• Tetraconazole
• Tributyl tetradecyl phosphonium chloride